Glomerular filtration: the charge debate charges ahead

被引：29

作者：

Miner, Jeffrey H. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO USA

[2] Washington Univ, Sch Med, Dept Cell Biol & Phys, St Louis, MO USA

来源：

KIDNEY INTERNATIONAL | 2008年 / 74卷 / 03期

关键词：

D O I：

10.1038/ki.2008.260

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.

引用

页码：259 / 261

页数：3

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