FT-IR microimaging spectroscopy: A comparison between healthy and neoplastic human colon tissues

被引：41

作者：

Conti, C. ^{[1
]}

Ferraris, P. ^{[1
]}

Giorgini, E. ^{[1
]}

Rubini, C. ^{[2
]}

Sabbatini, S. ^{[1
]}

Tosi, G. ^{[1
]}

Anastassopoulou, J. ^{[3
]}

Arapantoni, P. ^{[4
]}

Boukaki, E. ^{[3
]}

Konstadoudakis, S. ^{[4
]}

Theophanides, T. ^{[3
]}

Valavanis, C. ^{[4
]}

机构：

[1] Univ Politecn Marche, Dipartimento Sci & Tecnol Chim, I-60131 Ancona, Italy

[2] Univ Politecn Marche, Dipartimento Neurosci, I-60131 Ancona, Italy

[3] Natl Tech Univ Athens, Dept Chem Engn Radiat Chem & Biospect, Athens 15780, Greece

[4] Metaxa Hosp, Piraeus, Greece

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2008年 / 881卷 / 1-3期

关键词：

FT-IR microspectroscopy; NIR spectroscopy; colon adenocarcinoma; imaging;

D O I：

10.1016/j.molstruc.2007.08.040

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

FT-IR microimaging was performed on colon tissues with the aim to characterize spectral 'markers' to distinguish healthy from pathological tissues. Evidences of spectral peculiarities were mainly found in the finger print region even in the presence of a low grade adenocarcinoma. The occurrence of inflammation and necrotic states can also be demonstrated. Through statistical analysis as well as custom map procedures it was possible to reconstruct the topological distribution of different biochemical states and to verify results from the histopathological analysis. Preliminary results from FT-NIR analysis are in substantial agreement with those in the mid infrared region. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：46 / 51

页数：6

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