The Antiangiogenic and Antinociceptive Activities of n-Propyl Gallate

被引：13

作者：

Jung, H-J. ^{[3
]}

Lim, C-J. ^{[1
,2
]}

机构：

[1] Kangwon Natl Univ, Dept Biochem, Coll Nat Sci, Chunchon 200701, South Korea

[2] Kangwon Natl Univ, Life Sci Res Inst, Chunchon 200701, South Korea

[3] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2011年 / 25卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

n-propyl gallate; antiangiogenic; endostatin; antinociceptive; chorioallantoic membrane; ANGIOGENESIS INHIBITOR; HELA-CELLS; ENDOSTATIN; GROWTH; ARTHRITIS;

D O I：

10.1002/ptr.3452

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

n-Propyl gallate dose-dependently displayed an inhibitory effect on chick chorioallantoic membrane (CAM) angiogenesis. It markedly increased the endostatin level in both isolated CAM tissues and human umbilical vein endothelial cells (HUVECs). n-Propyl gallate was also able to enhance the endostatin mRNA level in HUVECs. Antinociceptive activity of n-propyl gallate was assessed using an acetic acid-induced writhing test in mice. In brief, n-propyl gallate possesses antiangiogenic activity via up-regulation of endostatin. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：1570 / 1573

页数：4

共 18 条

[1] The angiogenesis inhibitor, endostatin, does not affect murine cutaneous wound healing [J].

Berger, AC ;

Feldman, AL ;

Gnant, MFX ;

Kruger, EA ;

Sim, BKL ;

Hewitt, S ;

Figg, WD ;

Alexander, HR ;

Libutti, SK .

JOURNAL OF SURGICAL RESEARCH, 2000, 91 (01) :26-31

[2] Multiple pathogenic roles of microvasculature in inflammatory bowel disease: A jack of all trades [J].

Deban, Livija ;

Correale, Carmen ;

Vetrano, Stefania ;

Malesci, Alberto ;

Danese, Silvio .

AMERICAN JOURNAL OF PATHOLOGY, 2008, 172 (06) :1457-1466

[3] Propyl gallate inhibits the growth of HeLa cells via caspase-dependent apoptosis as well as a G1 phase arrest of the cell cycle [J].

Han, Yong Hwan ;

Moon, Hwa Jin ;

You, Bo Ra ;

Kim, Sung Zoo ;

Kim, Suhn Hee ;

Park, Woo Hyun .

ONCOLOGY REPORTS, 2010, 23 (04) :1153-1158

[4] Propyl gallate inhibits the growth of HeLa cells via regulating intracellular GSH level [J].

Han, Yong Hwan ;

Park, Woo Hyun .

FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (10) :2531-2538

[5]

Hebbar M, 2000, ARTHRITIS RHEUM-US, V43, P889, DOI 10.1002/1529-0131(200004)43:4<889::AID-ANR21>3.0.CO

[6]

2-5

[7] Anti-inflammatory Activity of n-Propyl Gallate Through Down-regulation of NF-κB and JNK Pathways [J].

Jung, Hyun-Joo ;

Kim, Su-Jung ;

Jeon, Woo-Kwang ;

Kim, Byung-Chul ;

Ahn, Kisup ;

Kim, Kyunghoon ;

Kim, Young-Myeong ;

Park, Eun-Hee ;

Lim, Chang-Jin .

INFLAMMATION, 2011, 34 (05) :352-361

[8] Protective effect of propyl gallate against myocardial oxidative stress-induced injury in rat [J].

Karthikeyan, K ;

Bai, BRS ;

Gauthaman, K ;

Devaraj, SN .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2005, 57 (01) :67-73

[9] Increased angiogenic response in aortic explants of collagen XVIII/endostatin-null mice [J].

Li, Q ;

Olsen, BR .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (02) :415-424

[10] Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells [J].

Ling, Yun ;

Yang, Yong ;

Lu, Na ;

You, Qi-Dong ;

Wang, Sen ;

Gao, Ying ;

Chen, Yan ;

Guo, Qing-Long .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 361 (01) :79-84

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