Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of Arg-Gly-Asp (RGD)

被引：11

作者：

Nishikawa, N

Komazawa, H

Orikasa, A

Yoshikane, M

Yamaguchi, J

Kojima, M

Ono, M

Itoh, I

Azuma, I

Fujii, H

Murata, J

Saiki, I

机构：

[1] HOKKAIDO UNIV,INST IMMUNOL SCI,SAPPORO,HOKKAIDO 060,JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,DEPT PATHOGEN BIOCHEM,SUGITANI,TOYAMA 93001,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(96)00494-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects on experimental lung metastasis of murine melanoma and adenosine 5'-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient therapeutic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation. Copyright (C) 1996 Elsevier Science Ltd

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页码：2725 / 2728

页数：4

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