Ni-Catalyzed Asymmetric Reductive Alkenylation of α-Chlorosulfones with Vinyl Bromides

被引：12

作者：

Geng, Jingjing ^{[1
]}

Sun, Deli ^{[1
]}

Song, Yanhong ^{[1
]}

Tong, Weiqi ^{[1
]}

Wu, Fan ^{[2
,3
]}

机构：

[1] Shanghai Univ, Ctr Supramol Chem & Catalysis, Dept Chem, Shanghai 200444, Peoples R China

[2] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Zhejiang, Peoples R China

[3] Ningbo Univ, Qian Xuesen Collaborat Res Ctr Astrochem & Space, Ningbo 315211, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 09期

基金：

中国国家自然科学基金;

关键词：

ANTIBACTERIAL; EPOXIDES; SULFONES; DESIGN; DRUGS; ACIDS;

D O I：

10.1021/acs.orglett.2c00217

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel-catalyzed enantioconvergent reductive cross-coupling of alpha-chlorosulfones with vinyl bromides is described here. This strategy enables the enantioselective construction of chiral allylic sulfones from simple alpha-chlorosulfones and vinyl bromides. The mild reaction conditions lead to excellent functional group compatibility, as evidenced by the broad substrate scope and tolerance of complex bioactive molecules. Our preliminary mechanistic study suggests that this enantioselective vinylation process operates through a radical intermediate.

引用

页码：1807 / 1811

页数：5

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