Modelling Mitochondrial Dysfunction in Mice

被引：13

作者：

Dogan, S. A. ^{[1
]}

Trifunovic, A. ^{[1
,2
]}

机构：

[1] Univ Cologne, Cologne, Germany

[2] Karolinska Inst, Div Metab Dis, Dept Lab Med, Stockholm, Sweden

来源：

PHYSIOLOGICAL RESEARCH | 2011年 / 60卷

关键词：

Mitochondrial diseases; mtDNA; Mouse models; Encephalomyopathies; Aging; TRANSCRIPTION FACTOR; DNA; MUTATIONS; GENE; EXPRESSION; MAINTENANCE; PHENOTYPES; DEPLETION; DEFECTS; SURF-1;

D O I：

10.33549/physiolres.932179

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Understanding mitochondrial role in normal physiology and pathological conditions has proven to be of high importance as mitochondrial dysfunction is connected with a number of disorders as well as some of the most common diseases (e. g. diabetes or Parkinson's disease). Modeling mitochondrial dysfunction has been difficult mainly due to unique features of mitochondrial genetics. Here we discuss some of the most important mouse models generated so far and lessons learned from them.

引用

页码：S61 / S70

页数：10

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