Zn(II) and Cu(II) complexes containing bioactive O,O-chelated ligands: homoleptic and heteroleptic metal-based biomolecules

被引：50
作者：
Mendiguchia, Barbara Sanz [1 ]
Aiello, Iolinda [1 ]
Crispini, Alessandra [1 ]
机构：
[1] Univ Calabria, Dipartimento Chim & Tecnol Chim, MAT INLAB Lab Mat Mol Inorgan, I-87036 Arcavacata Di Rende, Italy
来源：
DALTON TRANSACTIONS | 2015年 / 44卷 / 20期
关键词：
HINOKITIOL-RELATED COMPOUNDS; DNA-BINDING; IN-VITRO; COPPER(II) COMPLEXES; BETA-THUJAPLICIN; CRYSTAL-STRUCTURE; ZINC-COMPLEXES; CURCUMIN DERIVATIVES; MOLECULAR-MECHANISM; BIOLOGICAL-ACTIVITY;
D O I：
10.1039/c5dt00817d
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Historically, many useful drugs have been developed from natural sources and their mechanisms of action deeply investigated for therapeutic applications. Recently, the interaction between pharmacologically active biomolecules and transition metal ions has opened the way to the construction of new drugs, where the unique properties of metal complexes are combined with the specific mechanisms of action of the coordinated bioligands of natural extraction. In this context, this perspective summarizes some recent research studies devoted to the development of new metal-based drugs containing Zn(II) or Cu(II) metal ions. Both metals have a strong tendency to form highly stable complexes with N,N- and O,O-donor ligands bound through chelation, giving rise, particularly when the bound organic molecules are drug candidates of natural extraction, to drug delivery systems, new biologically active complexes and potential diagnostic agents due to their intrinsic spectroscopic properties.
引用
收藏
页码：9321 / 9334
页数：14
相关论文
共 50 条
[21]   Synthesis, spectral, electrochemical and catalytic properties of Cu(II), Ni(II) and Co(II) complexes containing N, O donors [J].
Raja, K. Kanmani ;
Easwaramoorthy, D. ;
Rani, S. Kutti ;
Rajesh, J. ;
Jorapur, Y. ;
Thambidurai, S. ;
Athappan, P. R. ;
Rajagopal, G. .
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 2009, 303 (1-2) :52-59
[22]   Syntheses and Crystal Structures of Cd(II) and Zn(II) Complexes Containing 2-Acetylpyridine-o-aminobenzoylhydrazone Ligand [J].
Huang Chao ;
Wu Juan ;
Chen Dong-Mei ;
Zhang Qi-Long ;
Zhu Bi-Xue .
CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2015, 31 (01) :109-113
[23]   Solution Equilibria of Ni(II), Cu(II), and Zn(II) Complexes Involving Pyridoxine and lmidazole Containing Ligands: pH Metric, Spectral, Electrochemical, and Biological Studies [J].
Neelakantan, M. A. ;
Sundaram, M. ;
Nair, M. Sivasankaran .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2011, 56 (05) :2527-2535
[24]   Synthesis, Spectral, Thermal Studies of Co(II), Ni(II), Cu(II) and Zn(II)-arginato Complexes. Crystal Structure of Monoaquabis(arginato-κO,κN) copper(II). [Cu(arg)2(H2O)]•NaNO3 [J].
Kose, Dursun Ali ;
Toprak, Emre ;
Avci, Emre ;
Avci, Gulcin Alp ;
Sahin, Onur ;
Buyukgungor, Orhan .
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2014, 61 (08) :881-890
[25]   Synthesis, characterization and nucleic acid binding studies of mononuclear copper(II) complexes derived from azo containing O, O donor ligands [J].
Tripathi, Mamta ;
Giri, Gopal Chandra ;
Das, Devashish ;
Pande, Rama ;
Sarkar, Sougata ;
Giri, Santanab ;
Roymahapatra, Gourisankar ;
Sarkar, Avijit .
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2018, 37 (10) :563-584
[26]   Spectroscopic, Thermal, and Antimicrobial Studies of Co(II), Ni(II), Cu(II), and Zn(II) Complexes Derived from Bidentate Ligands Containing N and S Donor Atoms [J].
Singh, Kiran ;
Kumar, Yogender ;
Puri, Parvesh ;
Singh, Gulab .
BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2012, 2012
[27]   Synthesis, spectroscopic characterization and biological activities of N4O2 Schiff base ligand and its metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) [J].
Al-Resayes, Saud I. ;
Shakir, Mohammad ;
Abbasi, Ambreen ;
Amin, Kr. Mohammad Yusuf ;
Lateef, Abdul .
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2012, 93 :86-94
[28]   TWO Zn(II)/Cu(II) COMPLEXES BASED ON FLEXIBLE MIXED LIGANDS: SYNTHESES, STRUCTURAL CHARACTERIZATION, AND LUMINESCENCE SENSING OF NITROBENZENE [J].
Y. Liu ;
W. Li ;
Y. -Q. Yang ;
M. -S. Chen ;
W. -W. Fu .
Journal of Structural Chemistry, 2021, 62 :1955-1961
[29]   TWO Zn(II)/Cu(II) COMPLEXES BASED ON FLEXIBLE MIXED LIGANDS: SYNTHESES, STRUCTURAL CHARACTERIZATION, AND LUMINESCENCE SENSING OF NITROBENZENE [J].
Liu, Y. ;
Li, W. ;
Yang, Y-Q ;
Chen, M-S ;
Fu, W-W .
JOURNAL OF STRUCTURAL CHEMISTRY, 2021, 62 (12) :1955-1961
[30]   Synthesis, characterization and crystal structures of copper(II) and nickel(II) complexes of propargyl arm containing N2O2 ligands: Antimicrobial activity and DNA binding [J].
Selvarani, V. ;
Annaraj, B. ;
Neelakantan, M. A. ;
Sundaramoorthy, S. ;
Velmurugan, D. .
POLYHEDRON, 2013, 54 :74-83
12345