Pd-Catalyzed One-Pot Two-Step Synthesis of 2-(1H-indol-3-yl)-2-phenylindolin-3-ones from 2-Alkynyl Arylazides and Indoles

被引：8

作者：

Yong, Wanxiong ^{[1
]}

Li, Ping ^{[1
]}

Sheng, Rong ^{[1
]}

Rao, Weidong ^{[1
]}

Zhang, Xiaoxiang ^{[1
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Key Lab Biomass Based Green Fuels & Chem, Nanjing 210037, Jiangsu, Peoples R China

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 41期

基金：

中国国家自然科学基金;

关键词：

2-Alkynyl Arylazides; Heterocycles; 2-(1H-indol-3-yl)-2-phenylindolin-3-ones; One-Pot; Palladium-Catalyzed; CARBENE MIGRATORY INSERTION; H BOND FUNCTIONALIZATION; CROSS-COUPLING REACTIONS; ENE-YNE-KETONES; DIAZO-COMPOUNDS; METAL CARBENE; C2-QUATERNARY INDOLIN-3-ONES; N-TOSYLHYDRAZONES; EXPEDITIOUS SYNTHESIS; CASCADE REACTIONS;

D O I：

10.1002/slct.201802476

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient palladium-catalyzed one-pot two-step reaction of 2-alkynyl arylazides and indoles has been developed. The reaction proceeded well under mild reaction conditions and provided the 2-(1H-indole-3-yl)-2-phenylindolin-3-ones in good to excellent yields.This transformation involves a rearrangement of 1H-indole-3-sulfonates generated in situ and Mannich-type addition of indoline-3-ones.

引用

页码：11696 / 11699

页数：4

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