Cancer and diet: How are they related?

被引：39
作者：
Sung, Bokyung [1 ]
Prasad, Sahdeo [1 ]
Yadav, Vivek R. [1 ]
Lavasanifar, Afsaneh [2 ]
Aggarwal, Bharat B. [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Cytokine Res Lab, Dept Expt Therapeut, Houston, TX 77030 USA
[2] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada
来源：
FREE RADICAL RESEARCH | 2011年 / 45卷 / 08期
基金：
美国国家卫生研究院;
关键词：
Dietary agents; inflammation; cancer; NF-KAPPA-B; ACTIVATED-RECEPTOR-GAMMA; ALPHA-KINASE ACTIVATION; REGULATED GENE-PRODUCTS; PROTEIN-TYROSINE-PHOSPHATASE; HUMAN MULTIPLE-MYELOMA; INDUCED CYCLOOXYGENASE-2 EXPRESSION; SIGNAL-TRANSDUCTION PATHWAYS; FACTOR E2-RELATED FACTOR-2; TRANSCRIPTION FACTOR NRF2;
D O I：
10.3109/10715762.2011.582869
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extensive research in the past decade has revealed cancer to be a multigenic disease caused by perturbation of multiple cell signalling pathways and dysregulation of numerous gene products, all of which have been linked to inflammation. It is also becoming evident that various lifestyle factors, such as tobacco and alcohol use, diet, environmental pollution, radiation and infections, can cause chronic inflammation and lead to tumourigenesis. Chronic diseases caused by ongoing inflammation therefore require chronic, not acute, treatment. Nutraceuticals, compounds derived from fruits, vegetables, spices and cereals, can be used chronically. This study discusses the molecular targets of some nutraceuticals that happen to be markers of chronic inflammation and how they can prevent or treat cancer. These naturally-occurring agents in the diet have great potential as anti-cancer drugs, thus proving Hippocrates, who proclaimed 25 centuries ago, 'Let food be thy medicine and medicine be thy food'.
引用
收藏
页码：864 / 879
页数：16
相关论文
共 225 条
[1]   Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer - Modern target but ancient solution [J].
Aggarwal, Bharat B. ;
Sethi, Gautam ;
Ahn, Kwang Seok ;
Sandur, Santosh K. ;
Pandey, Manoj K. ;
Kunnumakkara, Ajaikumar B. ;
Sung, Bokyung ;
Ichikawa, Haruyo .
SIGNAL TRANSDUCTION PATHWAYS, PT B: STRESS SIGNALING AND TRANSCRIPTIONAL CONTROL, 2006, 1091 :151-169
[2]   Inflammation and cancer: How hot is the link? [J].
Aggarwal, Bharat B. ;
Shishodia, Shishir ;
Sandur, Santosh K. ;
Pandey, Manoj K. ;
Sethi, Gautam .
BIOCHEMICAL PHARMACOLOGY, 2006, 72 (11) :1605-1621
[3]   Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer How Intimate Is the Relationship? [J].
Aggarwal, Bharat B. ;
Kunnumakkara, Ajaikurnar B. ;
Harikumar, Kuzhuvelil B. ;
Gupta, Shan R. ;
Tharakan, Sheeja T. ;
Koca, Cemile ;
Dey, Sanjit ;
Sung, Bokyung .
NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS, 2009, 1171 :59-76
[4]   Inflammation and cancer: how friendly is the relationship for cancer patients? [J].
Aggarwal, Bharat B. ;
Gehlot, Prashasnika .
CURRENT OPINION IN PHARMACOLOGY, 2009, 9 (04) :351-369
[5]   Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe [J].
Aggarwal, Bharat B. ;
Vijayalekshmi, R. V. ;
Sung, Bokyung .
CLINICAL CANCER RESEARCH, 2009, 15 (02) :425-430
[6]   Nuclear factor-kappa B: From clone to clinic [J].
Ahn, Kwang Seok ;
Sethi, Gautam ;
Aggarwal, Bharat B. .
CURRENT MOLECULAR MEDICINE, 2007, 7 (07) :619-637
[7]   Simvastatin potentiates TNF-α-induced apoptosis through the down-regulation of NF-κB-dependent antiapoptotic gene products:: Role of IκBα kinase and TGF-β-activated kinase-1 [J].
Ahn, Kwang Seok ;
Sethi, Gautam ;
Aggarwal, Bharat B. .
JOURNAL OF IMMUNOLOGY, 2007, 178 (04) :2507-2516
[8]   γ-tocotrienol inhibits nuclear factor-κB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and Potentiation of apoptosis [J].
Ahn, Kwang Seok ;
Sethi, Gautam ;
Krishnan, Koyamangalath ;
Aggarwal, Bharat B. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (01) :809-820
[9]   MOLECULAR-CLONING OF APRF, A NOVEL IFN-STIMULATED GENE FACTOR-3 P91-RELATED TRANSCRIPTION FACTOR INVOLVED IN THE GP130-MEDIATED SIGNALING PATHWAY [J].
AKIRA, S ;
NISHIO, Y ;
INOUE, M ;
WANG, XJ ;
WEI, S ;
MATSUSAKA, T ;
YOSHIDA, K ;
SUDO, T ;
NARUTO, M ;
KISHIMOTO, T .
CELL, 1994, 77 (01) :63-71
[10]   RETRACTED: Modification of Cysteine Residue in p65 Subunit of Nuclear Factor-κB (NF-κB) by Picroliv Suppresses NF-κB-Regulated Gene Products and Potentiates Apoptosis (Retracted article. See vol. 78, pg. 5187, 2018) [J].
Anand, Preetha ;
Kunnumakkara, Ajaikumar B. ;
Harikumar, Kuzhuvelil B. ;
Ahn, Kwang Seok ;
Badmaev, Vladimir ;
Aggarwal, Bharat B. .
CANCER RESEARCH, 2008, 68 (21) :8861-8870
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