Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

被引：38

作者：

Ganguly, Swastika ^{[1
]}

Vithlani, Vatsal Vijay ^{[1
]}

Kesharwani, Anup Kumar ^{[1
]}

Kuhu, Ritu ^{[1
]}

Baskar, Lakshmanan ^{[1
]}

Mitramazumder, Papiya ^{[1
]}

Sharon, Ashok ^{[2
]}

Dev, Abhimanyu ^{[1
]}

机构：

[1] Birla Inst Technol, Dept Pharmaceut Sci, Ranchi 835215, Jharkhand, India

[2] Birla Inst Technol, Dept Appl Chem, Ranchi 835215, Jharkhand, India

来源：

ACTA PHARMACEUTICA | 2011年 / 61卷 / 02期

关键词：

imidazole; reverse transcriptase; non-nucleoside reverse transcriptase; anti-HIV; antibacterial; REVERSE-TRANSCRIPTASE INHIBITORS; BIOLOGICAL EVALUATION; DESIGN; CHEMOTHERAPY; BINDING; SERIES; MODE;

D O I：

10.2478/v10007-011-0018-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[ arylmethoxy] ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxy-phenyl)-2-(substituted imidazol-1-yl) alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.

引用

页码：187 / 201

页数：15

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