Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

被引：38
|
作者：
Ganguly, Swastika [1 ]
Vithlani, Vatsal Vijay [1 ]
Kesharwani, Anup Kumar [1 ]
Kuhu, Ritu [1 ]
Baskar, Lakshmanan [1 ]
Mitramazumder, Papiya [1 ]
Sharon, Ashok [2 ]
Dev, Abhimanyu [1 ]
机构：
[1] Birla Inst Technol, Dept Pharmaceut Sci, Ranchi 835215, Jharkhand, India
[2] Birla Inst Technol, Dept Appl Chem, Ranchi 835215, Jharkhand, India
来源：
ACTA PHARMACEUTICA | 2011年 / 61卷 / 02期
关键词：
imidazole; reverse transcriptase; non-nucleoside reverse transcriptase; anti-HIV; antibacterial; REVERSE-TRANSCRIPTASE INHIBITORS; BIOLOGICAL EVALUATION; DESIGN; CHEMOTHERAPY; BINDING; SERIES; MODE;
D O I：
10.2478/v10007-011-0018-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[ arylmethoxy] ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxy-phenyl)-2-(substituted imidazol-1-yl) alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.
引用
收藏
页码：187 / 201
页数：15
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