Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

被引：41

作者：

Ganguly, Swastika ^{[1
]}

Vithlani, Vatsal Vijay ^{[1
]}

Kesharwani, Anup Kumar ^{[1
]}

Kuhu, Ritu ^{[1
]}

Baskar, Lakshmanan ^{[1
]}

Mitramazumder, Papiya ^{[1
]}

Sharon, Ashok ^{[2
]}

Dev, Abhimanyu ^{[1
]}

机构：

[1] Birla Inst Technol, Dept Pharmaceut Sci, Ranchi 835215, Jharkhand, India

[2] Birla Inst Technol, Dept Appl Chem, Ranchi 835215, Jharkhand, India

来源：

ACTA PHARMACEUTICA | 2011年 / 61卷 / 02期

关键词：

imidazole; reverse transcriptase; non-nucleoside reverse transcriptase; anti-HIV; antibacterial; REVERSE-TRANSCRIPTASE INHIBITORS; BIOLOGICAL EVALUATION; DESIGN; CHEMOTHERAPY; BINDING; SERIES; MODE;

D O I：

10.2478/v10007-011-0018-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[ arylmethoxy] ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxy-phenyl)-2-(substituted imidazol-1-yl) alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.

引用

页码：187 / 201

页数：15

共 18 条

[1] ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].

BARRESINOUSSI, F ;

CHERMANN, JC ;

REY, F ;

NUGEYRE, MT ;

CHAMARET, S ;

GRUEST, J ;

DAUGUET, C ;

AXLERBLIN, C ;

VEZINETBRUN, F ;

ROUZIOUX, C ;

ROZENBAUM, W ;

MONTAGNIER, L .

SCIENCE, 1983, 220 (4599) :868-871

[2] New developments in anti-HIV chemotherapy [J].

De Clercq, E .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2002, 1587 (2-3) :258-275

[3] Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation [J].

De Martino, G ;

La Regina, G ;

Di Pasquali, A ;

Ragno, R ;

Bergamini, A ;

Ciaprini, C ;

Sinistro, A ;

Maga, G ;

Crespan, E ;

Artico, M ;

Silvestri, R .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (13) :4378-4388

[4] TOWARD IMPROVED ANTI-HIV CHEMOTHERAPY - THERAPEUTIC STRATEGIES FOR INTERVENTION WITH HIV-INFECTIONS [J].

DECLERCQ, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (14) :2491-2517

[5] FREQUENT DETECTION AND ISOLATION OF CYTOPATHIC RETROVIRUSES (HTLV-III) FROM PATIENTS WITH AIDS AND AT RISK FOR AIDS [J].

GALLO, RC ;

SALAHUDDIN, SZ ;

POPOVIC, M ;

SHEARER, GM ;

KAPLAN, M ;

HAYNES, BF ;

PALKER, TJ ;

REDFIELD, R ;

OLESKE, J ;

SAFAI, B ;

WHITE, G ;

FOSTER, P ;

MARKHAM, PD .

SCIENCE, 1984, 224 (4648) :500-503

[6]

Ganguly S., 2009, INT J CHEM SCI, V7, P204

[7] Synthesis and Anti-HIV-1 Activity of a Novel Series of Aminoimidazole Analogs [J].

Ganguly, Swastika ;

Murugesan, Sankaran ;

Prasanthi, Naru ;

Alpturk, Onur ;

Herman, Brian ;

Sluis-Cremer, Nicolas .

LETTERS IN DRUG DESIGN & DISCOVERY, 2010, 7 (05) :318-323

[8] SYNTHESIS AND ANTIPROTOZOAL ACTIVITY OF 1-(3-CHLORO-2-HYDROXYPROPYL)-SUBSTITUTED NITROIMIDAZOLES [J].

HOFFER, M ;

GRUNBERG, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (09) :1019-1020

[9] Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors [J].

Hopkins, AL ;

Ren, JS ;

Esnouf, RM ;

Willcox, BE ;

Jones, EY ;

Ross, C ;

Miyasaka, T ;

Walker, RT ;

Tanaka, H ;

Stammers, DK ;

Stuart, DI .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (08) :1589-1600

[10] Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids [J].

Jorgensen, WL ;

Maxwell, DS ;

TiradoRives, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (45) :11225-11236

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