Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

被引：38

作者：

Ganguly, Swastika ^{[1
]}

Vithlani, Vatsal Vijay ^{[1
]}

Kesharwani, Anup Kumar ^{[1
]}

Kuhu, Ritu ^{[1
]}

Baskar, Lakshmanan ^{[1
]}

Mitramazumder, Papiya ^{[1
]}

Sharon, Ashok ^{[2
]}

Dev, Abhimanyu ^{[1
]}

机构：

[1] Birla Inst Technol, Dept Pharmaceut Sci, Ranchi 835215, Jharkhand, India

[2] Birla Inst Technol, Dept Appl Chem, Ranchi 835215, Jharkhand, India

来源：

ACTA PHARMACEUTICA | 2011年 / 61卷 / 02期

关键词：

imidazole; reverse transcriptase; non-nucleoside reverse transcriptase; anti-HIV; antibacterial; REVERSE-TRANSCRIPTASE INHIBITORS; BIOLOGICAL EVALUATION; DESIGN; CHEMOTHERAPY; BINDING; SERIES; MODE;

D O I：

10.2478/v10007-011-0018-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[ arylmethoxy] ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxy-phenyl)-2-(substituted imidazol-1-yl) alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.

引用

页码：187 / 201

页数：15

共 18 条

[1] ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS)
BARRESINOUSSI, F
CHERMANN, JC
REY, F
NUGEYRE, MT
CHAMARET, S
GRUEST, J
DAUGUET, C
AXLERBLIN, C
VEZINETBRUN, F
ROUZIOUX, C
ROZENBAUM, W
MONTAGNIER, L
[J]. SCIENCE, 1983, 220 (4599) : 868 - 871
[2] New developments in anti-HIV chemotherapy
De Clercq, E
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2002, 1587 (2-3): : 258 - 275
[3] Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation
De Martino, G
La Regina, G
Di Pasquali, A
Ragno, R
Bergamini, A
Ciaprini, C
Sinistro, A
Maga, G
Crespan, E
Artico, M
Silvestri, R
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (13) : 4378 - 4388
[4] TOWARD IMPROVED ANTI-HIV CHEMOTHERAPY - THERAPEUTIC STRATEGIES FOR INTERVENTION WITH HIV-INFECTIONS
DECLERCQ, E
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (14) : 2491 - 2517
[5] FREQUENT DETECTION AND ISOLATION OF CYTOPATHIC RETROVIRUSES (HTLV-III) FROM PATIENTS WITH AIDS AND AT RISK FOR AIDS
GALLO, RC
SALAHUDDIN, SZ
POPOVIC, M
SHEARER, GM
KAPLAN, M
HAYNES, BF
PALKER, TJ
REDFIELD, R
OLESKE, J
SAFAI, B
WHITE, G
FOSTER, P
MARKHAM, PD
[J]. SCIENCE, 1984, 224 (4648) : 500 - 503
[6] Ganguly S., 2009, INT J CHEM SCI, V7, P204
[7] Synthesis and Anti-HIV-1 Activity of a Novel Series of Aminoimidazole Analogs
Ganguly, Swastika
Murugesan, Sankaran
Prasanthi, Naru
Alpturk, Onur
Herman, Brian
Sluis-Cremer, Nicolas
[J]. LETTERS IN DRUG DESIGN & DISCOVERY, 2010, 7 (05) : 318 - 323
[8] SYNTHESIS AND ANTIPROTOZOAL ACTIVITY OF 1-(3-CHLORO-2-HYDROXYPROPYL)-SUBSTITUTED NITROIMIDAZOLES
HOFFER, M
GRUNBERG, E
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (09) : 1019 - 1020
[9] Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors
Hopkins, AL
Ren, JS
Esnouf, RM
Willcox, BE
Jones, EY
Ross, C
Miyasaka, T
Walker, RT
Tanaka, H
Stammers, DK
Stuart, DI
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (08) : 1589 - 1600
[10] Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids
Jorgensen, WL
Maxwell, DS
TiradoRives, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (45) : 11225 - 11236

← 1 2 →