Update on the role of C1GALT1 in cancer (Review)

被引：5
|
作者：
Xia, Tong [1 ]
Xiang, Ting [1 ]
Xie, Hailong [1 ]
机构：
[1] Univ South China, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Inst Canc Res, Sch Med, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China
来源：
ONCOLOGY LETTERS | 2022年 / 23卷 / 03期
关键词：
glycan; glycosylation; glycosyltransferase; core 1 beta 1,3-galactosyltransferase; T-synthase; HEPATOCELLULAR-CARCINOMA CELLS; PREDICTS POOR-PROGNOSIS; BREAST-CANCER; O-GLYCOSYLATION; EPH RECEPTORS; IN-VITRO; PROTEIN GLYCOSYLATION; MOLECULAR CHAPERONE; C-MET; SPONTANEOUS COLITIS;
D O I：
10.3892/ol.2022.13217
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer remains one of the most difficult diseases to treat. In the quest for early diagnoses to improve patient survival and prognosis, targeted therapies have become a hot research topic in recent years. Glycosylation is the most common posttranslational modification in mammalian cells. Core 1 beta 1,3-galactosyltransferase (C1GALT1) is a key glycosyltransferase in the glycosylation process and is the key enzyme in the formation of the core 1 structure on which most complex and branched O-glycans are formed. A recent study reported that C1GALT1 was aberrantly expressed in tumors. In cancer cells, C1GALT1 is regulated by different factors. In the present review, the expression of C1GALT1 in different tumors and its possible molecular mechanisms of action are described and the role of C1GALT1 in cancer development is discussed.
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页数：11
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