BREAST CANCER The 21-gene recurrence score - biology remains at the forefront

被引：3
作者：
Puhalla, Shannon L. [1 ]
Davidson, Nancy E. [1 ]
机构：
[1] Univ Pittsburgh, Inst Canc, Dept Med, 5150 Ctr Ave, Pittsburgh, PA 15232 USA
来源：
NATURE REVIEWS CLINICAL ONCOLOGY | 2016年 / 13卷 / 08期
关键词：
DISTANT RECURRENCE; EXPRESSION; THERAPY; WOMEN; RISK;
D O I：
10.1038/nrclinonc.2016.98
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The 21-gene recurrence score is a genetic assay developed to estimate the likelihood of distant recurrence in patients with oestrogen-receptor-positive, lymph-node-negative breast cancer treated with adjuvant endocrine therapy. Now, two studies explore how the 21-gene recurrence score has been used to inform treatment decisions in this setting and beyond.
引用
收藏
页码：470 / 472
页数：2
相关论文
共 10 条
  • [1] ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2)
    Cardoso, F.
    Costa, A.
    Norton, L.
    Senkus, E.
    Aapro, M.
    Andre, F.
    Barrios, C. H.
    Bergh, J.
    Biganzoli, L.
    Blackwell, K. L.
    Cardoso, M. J.
    Cufer, T.
    El Saghir, N.
    Fallowfield, L.
    Fenech, D.
    Francis, P.
    Gelmon, K.
    Giordano, S. H.
    Gligorov, J.
    Goldhirsch, A.
    Harbeck, N.
    Houssami, N.
    Hudis, C.
    Kaufman, B.
    Krop, I.
    Kyriakides, S.
    Lin, U. N.
    Mayer, M.
    Merjaver, S. D.
    Nordstrom, E. B.
    Pagani, O.
    Partridge, A.
    Penault-Llorca, F.
    Piccart, M. J.
    Rugo, H.
    Sledge, G.
    Thomssen, C.
    van't Veer, L.
    Vorobiof, D.
    Vrieling, C.
    West, N.
    Xu, B.
    Winer, E.
    [J]. BREAST, 2014, 23 (05) : 489 - 502
  • [2] A New Molecular Predictor of Distant Recurrence in ER-Positive, HER2-Negative Breast Cancer Adds Independent Information to Conventional Clinical Risk Factors
    Filipits, Martin
    Rudas, Margaretha
    Jakesz, Raimund
    Dubsky, Peter
    Fitzal, Florian
    Singer, Christian F.
    Dietze, Otto
    Greil, Richard
    Jelen, Andrea
    Sevelda, Paul
    Freibauer, Christa
    Mueller, Volkmar
    Jaenicke, Fritz
    Schmidt, Marcus
    Koelbl, Heinz
    Rody, Achim
    Kaufmann, Manfred
    Schroth, Werner
    Brauch, Hiltrud
    Schwab, Matthias
    Fritz, Peter
    Weber, Karsten E.
    Feder, Inke S.
    Hennig, Guido
    Kronenwett, Ralf
    Gehrmann, Mathias
    Gnant, Michael
    [J]. CLINICAL CANCER RESEARCH, 2011, 17 (18) : 6012 - 6020
  • [3] Predicting distant recurrence in receptor-positive breast cancer patients with limited clinicopathological risk: using the PAM50 Risk of Recurrence score in 1478 postmenopausal patients of the ABCSG-8 trial treated with adjuvant endocrine therapy alone
    Gnant, M.
    Filipits, M.
    Greil, R.
    Stoeger, H.
    Rudas, M.
    Bago-Horvath, Z.
    Mlineritsch, B.
    Kwasny, W.
    Knauer, M.
    Singer, C.
    Jakesz, R.
    Dubsky, P.
    Fitzal, F.
    Bartsch, R.
    Steger, G.
    Balic, M.
    Ressler, S.
    Cowens, J. W.
    Storhoff, J.
    Ferree, S.
    Schaper, C.
    Liu, S.
    Fesl, C.
    Nielsen, T. O.
    [J]. ANNALS OF ONCOLOGY, 2014, 25 (02) : 339 - 345
  • [4] Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline
    Harris, Lyndsay N.
    Ismaila, Nofisat
    McShane, Lisa M.
    Andre, Fabrice
    Collyar, Deborah E.
    Gonzalez-Angulo, Ana M.
    Hammond, Elizabeth H.
    Kuderer, Nicole M.
    Liu, Minetta C.
    Mennel, Robert G.
    Van Poznak, Catherine
    Bast, Robert C.
    Hayes, Daniel F.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (10) : 1134 - +
  • [5] Jasem J., 2016, J CLIN ONCOL
  • [6] King T. A., 2016, J CLIN ONCOL
  • [7] Prediction of the Oncotype DX recurrence score: use of pathology-generated equations derived by linear regression analysis
    Klein, Molly E.
    Dabbs, David J.
    Shuai, Yongli
    Brufsky, Adam M.
    Jankowitz, Rachel
    Puhalla, Shannon L.
    Bhargava, Rohit
    [J]. MODERN PATHOLOGY, 2013, 26 (05) : 658 - 664
  • [8] Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    Paik, Soonmyung
    Tang, Gong
    Shak, Steven
    Kim, Chungyeul
    Baker, Joffre
    Kim, Wanseop
    Cronin, Maureen
    Baehner, Frederick L.
    Watson, Drew
    Bryant, John
    Costantino, Joseph P.
    Geyer, Charles E., Jr.
    Wickerham, D. Lawrence
    Wolmark, Norman
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (23) : 3726 - 3734
  • [9] Piccart M, 2016, AM ASS CANC RES ANN
  • [10] Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
    Sparano, J. A.
    Gray, R. J.
    Makower, D. F.
    Pritchard, K. I.
    Albain, K. S.
    Hayes, D. F.
    Geyer, C. E., Jr.
    Dees, E. C.
    Perez, E. A.
    Olson, J. A., Jr.
    Zujewski, J. A.
    Lively, T.
    Badve, S. S.
    Saphner, T. J.
    Wagner, L. I.
    Whelan, T. J.
    Ellis, M. J.
    Paik, S.
    Wood, W. C.
    Ravdin, P.
    Keane, M. M.
    Gomez Moreno, H. L.
    Reddy, P. S.
    Goggins, T. F.
    Mayer, I. A.
    Brufsky, A. M.
    Toppmeyer, D. L.
    Kaklamani, V. G.
    Atkins, J. N.
    Berenberg, J. L.
    Sledge, G. W.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (21) : 2005 - 2014
1