Applying the principles of stem-cell biology to cancer

被引：1244

作者：

Pardal, R

Clarke, MF

Morrison, SJ

机构：

[1] Univ Michigan, Howard Hughes Med Inst, CCGC 3215, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med, CCGC 3215, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Cell & Dev Biol, CCGC 3215, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Internal Med, CCGC 4310, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Cell & Dev Biol, CCGC 4310, Ann Arbor, MI 48109 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 12期

关键词：

D O I：

10.1038/nrc1232

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Why are tumours heterogeneous, in terms of cell phenotype and proliferative potential, even in cases in which all cells are derived from a single clone? Ongoing mutagenesis can partially explain this heterogeneity, but it also seems that some tumours arise from small populations of 'cancer stem cells' that give rise to phenotypically diverse cancer cells, with less proliferative potential. These cancer stem cells are likely to arise from mutations that dysregulate normal stem-cell self-renewal. Using this information, it might be possible to devise more effective therapies.

引用

页码：895 / 902

页数：8

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