Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference

被引:24
|
作者
Rozeske, Robert R. [1 ]
Greenwood, Benjamin N. [2 ]
Fleshner, Monika [2 ]
Watkins, Linda R. [1 ]
Maier, Steven F. [1 ]
机构
[1] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA
[2] Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA
基金
美国国家卫生研究院;
关键词
Exercise; Stress; Morphine; Addiction; Serotonin; Learned helplessness; DORSAL RAPHE NUCLEUS; SEROTONIN EFFLUX; UNCONTROLLABLE STRESS; 5-HT1A AUTORECEPTORS; INDUCED DOPAMINE; CONTROLLABILITY; EXERCISE; RATS; DESENSITIZATION; REINSTATEMENT;
D O I
10.1016/j.bbr.2011.01.030
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
In rodents, exposure to acute inescapable, but not escapable, stress potentiates morphine conditioned place preference (CPP), an effect that is dependent upon hyperactivation of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN). Six weeks of voluntary wheel running constrains activation of DRN 5-HT neurons during exposure to inescapable stress. Six weeks of voluntary wheel running before inescapable stress blocked stress-induced potentiation of morphine CPP. Published by Elsevier B.V.
引用
收藏
页码:378 / 381
页数:4
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