Gastrointestinal, Pancreatic, and Hepatobiliary Manifestations of Cystic Fibrosis

被引：30

作者：

Sathe, Meghana Nitin ^{[1
]}

Freeman, Alvin Jay ^{[2
]}

机构：

[1] Univ Texas Southwestern, Childrens Hlth, Div Pediat Gastroenterol & Nutr, F4-06,1935 Med Dist Dr, Dallas, TX 75235 USA

[2] Emory Univ, Div Pediat Gastroenterol Hepatol & Nutr, Childrens Healthcare Atlanta, 2015 Uppergate Dr Northeast, Atlanta, GA 30322 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2016年 / 63卷 / 04期

关键词：

CF and GI manifestations; CF pancreas; CFLD (CF liver disease); PERT (pancreatic enzyme replacement therapy); CLOSTRIDIUM-DIFFICILE COLITIS; LIVER-DISEASE; BACTERIAL OVERGROWTH; HELICOBACTER-PYLORI; ABDOMINAL MANIFESTATIONS; GASTROESOPHAGEAL-REFLUX; INTESTINAL-OBSTRUCTION; ENZYME SUPPLEMENTS; FECAL ELASTASE-1; DUODENAL-ULCER;

D O I：

10.1016/j.pcl.2016.04.008

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Pulmonary disease is the primary cause of morbidity and mortality in people with cystic fibrosis (CF), but significant involvement within gastrointestinal, pancreatic, and hepatobiliary systems occurs as well. As in the airways, defects in CFTR alter epithelial surface fluid, mucus viscosity, and pH, increasing risk of stasis through the various hollow epithelial-lined structures of the gastrointestinal tract. This exerts secondary influences that are responsible for most gastrointestinal, pancreatic, and hepatobiliary manifestations of CF. Understanding these gastrointestinal morbidities of CF is essential in understanding and treating CF as a multisystem disease process and improving overall patient care.

引用

页码：679 / +

页数：22

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