Multiple determinants of lifespan memory differences

被引：53

作者：

Henson, Richard N. ^{[1
,2
,3
]}

Campbell, Karen L. ^{[2
,3
,4
]}

Davis, Simon W. ^{[2
,3
,5
]}

Taylor, Jason R. ^{[2
,3
,6
]}

Emery, Tina ^{[1
,2
,3
]}

Erzinclioglu, Sharon ^{[1
,2
,3
]}

Kievit, Rogier A. ^{[1
,2
,3
]}

机构：

[1] MRC, Cognit & Brain Sci Unit, Cambridge, England

[2] Univ Cambridge, Cambridge Ctr Ageing & Neurosci, Cambridge, England

[3] MRC Cognit & Brain Sci Unit, Cambridge, England

[4] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA

[5] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27706 USA

[6] Univ Manchester, Sch Biol Sci, Manchester M13 9PL, Lancs, England

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

ADULT AGE-DIFFERENCES; MEDIAL TEMPORAL-LOBE; WHITE-MATTER; EPISODIC MEMORY; IMPLICIT MEMORY; RECOGNITION; FAMILIARITY; DECLINE; INTELLIGENCE; NEUROSCIENCE;

D O I：

10.1038/srep32527

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Memory problems are among the most common complaints as people grow older. Using structural equation modeling of commensurate scores of anterograde memory from a large (N = 315), population-derived sample (www.cam-can.org), we provide evidence for three memory factors that are supported by distinct brain regions and show differential sensitivity to age. Associative memory and item memory are dramatically affected by age, even after adjusting for education level and fluid intelligence, whereas visual priming is not. Associative memory and item memory are differentially affected by emotional valence, and the age-related decline in associative memory is faster for negative than for positive or neutral stimuli. Gray-matter volume in the hippocampus, parahippocampus and fusiform cortex, and a white-matter index for the fornix, uncinate fasciculus and inferior longitudinal fasciculus, show differential contributions to the three memory factors. Together, these data demonstrate the extent to which differential ageing of the brain leads to differential patterns of memory loss.

引用

页数：14

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