Functional genomics and target validation approaches using antisense oligonucleotide technology

被引：57
作者：
Dean, NM [1 ]
机构：
[1] GeneTrove, Dept Funct Genom, Carlsbad, CA 92008 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2001年 / 12卷 / 06期
关键词：
D O I：
10.1016/S0958-1669(01)00270-1
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The recent increase in the amount and rate of accumulation of genomic information has created new challenges for the pharmaceutical industry. These include how best to rapidly and efficiently identify key genes responsible for complex disease phenotypes and how to use this information to develop new and specific classes of drugs. Antisense technology offers a powerful approach to identify novel cellular networks and signaling cassettes' and provides a method to validate genes in vivo as attractive drug targets.
引用
收藏
页码：622 / 625
页数：4
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