Photocyanine: A novel and effective phthalocyanine-based photosensitizer for cancer treatment

被引:38
作者
Chen, Dan [1 ]
Song, Meiru [1 ]
Huang, Jinling [1 ]
Chen, Naishen [1 ]
Xue, Jinping [1 ]
Huang, Mingdong [1 ]
机构
[1] Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China
基金
国家重点研发计划;
关键词
Photosensitizer; photodynamic therapy; cancer; Photocyanine; HEPATOCELLULAR-CARCINOMA HEPG2; PHOTODYNAMIC THERAPY; LIGHT-SOURCES; MECHANISMS; PORPHYRIN; CELLS;
D O I
10.1142/S1793545820300098
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
As one of the three key components of photodynamic therapy (PDT), photosensitizers (PSs) greatly influence the photodynamic efficiency in the treatment of tumors. Photosensitizers with tetrapyrrole structure, such as porphyrins, chlorins and phthalocyanines, have been extensively investigated for PDT and some of them have already received clinical approval. However, only a few of porphyrin-based photosensitizers are available for clinical applications, and PDT has not received wide recognition in clinical practice. In this regard, PSs remain a limiting factor. Our research focuses on the rational design of new PSs. Photocyanine, a Zinc (II) phthalocyanine (ZnPc) type photosensitizer with low dark toxicity and high single oxygen quantum yield, is one of the promising PSs candidates and currently being tested in clinical trials. Here, we present an overview on the development of Photocyanine, including its design, synthesis, purification, characterization and preclinical studies, wishing to contribute to the research of more promising PSs.
引用
收藏
页数:13
相关论文
共 40 条
[1]   Photodynamic Therapy of Cancer: An Update [J].
Agostinis, Patrizia ;
Berg, Kristian ;
Cengel, Keith A. ;
Foster, Thomas H. ;
Girotti, Albert W. ;
Gollnick, Sandra O. ;
Hahn, Stephen M. ;
Hamblin, Michael R. ;
Juzeniene, Asta ;
Kessel, David ;
Korbelik, Mladen ;
Moan, Johan ;
Mroz, Pawel ;
Nowis, Dominika ;
Piette, Jacques ;
Wilson, Brian C. ;
Golab, Jakub .
CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (04) :250-281
[2]   BIOLOGICAL-ACTIVITIES OF PHTHALOCYANINES .10. SYNTHESES AND ANALYSES OF SULFONATED PHTHALOCYANINES [J].
ALI, H ;
LANGLOIS, R ;
WAGNER, JR ;
BRASSEUR, N ;
PAQUETTE, B ;
VANLIER, JE .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1988, 47 (05) :713-717
[4]   Laser and non-laser light sources for photodynamic therapy [J].
Brancaleon, L ;
Moseley, H .
LASERS IN MEDICAL SCIENCE, 2002, 17 (03) :173-186
[5]   The present and future role of photodynamic therapy in cancer treatment [J].
Brown, SB ;
Brown, EA ;
Walker, I .
LANCET ONCOLOGY, 2004, 5 (08) :497-508
[6]   STEPWISE SYNTHESIS OF SOLUBLE SUBSTITUTED TRIAZOLEPHTHALOCYANINES [J].
CABEZON, B ;
RODRIGUEZMORGADE, S ;
TORRES, T .
JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (06) :1872-1874
[7]   Mechanisms in photodynamic therapy: Part three- Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction [J].
Castano, Ana P. ;
Demidova, Tatiana N. ;
Hamblin, Michael R. .
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2005, 2 (02) :91-106
[8]   Photoactivation switch from type II to type I reactions by electron-rich micelles for improved photodynamic therapy of cancer cells under hypoxia [J].
Ding, Huiying ;
Yu, Haijun ;
Dong, Ying ;
Tian, Ruhai ;
Huang, Gang ;
Boothman, David A. ;
Sumer, Baran D. ;
Gao, Jinming .
JOURNAL OF CONTROLLED RELEASE, 2011, 156 (03) :276-280
[9]   Photodynamic therapy for cancer [J].
Dolmans, DEJGJ ;
Fukumura, D ;
Jain, RK .
NATURE REVIEWS CANCER, 2003, 3 (05) :380-387
[10]   Characterization of Photofrin photobleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cells in vitro [J].
Dysart, JS ;
Patterson, MS .
PHYSICS IN MEDICINE AND BIOLOGY, 2005, 50 (11) :2597-2616