Insulin signaling pathways and cardiac growth

被引：47

作者：

DeBosch, Brian J.

Muslin, Anthony J.

机构：

[1] Washington Univ, Sch Med, Cardiovasc Res Ctr, John Milliken Dept Internal Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2008年 / 44卷 / 05期

关键词：

insulin; IGF; cardiac growth; signal transduction; signaling; diabetes; diabetic cardiomyopathy; heart failure; hypertrophy;

D O I：

10.1016/j.yjmcc.2008.03.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed. Published by Elsevier Inc.

引用

页码：855 / 864

页数：10

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