Cytotoxic triterpenoid saponins from Aesculus glabra Willd.

被引：20

作者：

Yuan, Wei ^{[1
]}

Wang, Ping ^{[1
]}

Deng, Guangrui ^{[1
]}

Li, Shiyou ^{[1
]}

机构：

[1] Stephen F Austin State Univ, Natl Ctr Pharmaceut Crops, Arthur Temple Coll Forestry & Agr, Nacogdoches, TX 75972 USA

来源：

PHYTOCHEMISTRY | 2012年 / 75卷

关键词：

Aesculus glabra; Hippocastanaceae; Triterpenoid saponins; Cytotoxicity; Aesculioside; Chemotaxonomy; HYPOGLYCEMIC ACTIVITY; ASSAMICA GRIFF; HORSE CHESTNUT; SYMPLOCOS-CHINENSIS; ETHANOL ABSORPTION; BIOACTIVE SAPONINS; HIPPOCASTANUM L; WOODEN ASHES; PAVIA L; SEEDS;

D O I：

10.1016/j.phytochem.2011.11.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty-four acylated polyhydroxyoleanene saponins were isolated from the seeds of Aesculus glabra. Sixteen of them, namely aesculiosides G1-G16 (1-16), were determined as compounds by spectroscopic and chemical analysis. The structural features of all 24 saponins are: (1) arabinofuranosyl units affixed to C-3 of the glucuronopyranosyl unit in the trisaccharide chain; (2) no 24-OH substitution: (3) C-2 sugar moiety substitution of the 3-O-glucuronopyranosyl unit is either glucopyranosyl or galactopyranosyl. The features of these isolated saponin structures provide more evidence for chemical taxonomy within the genus Aesculus. The cytotoxicity of the aesculiosides (1-16) were tested against A549 and PC-3 cancer cell lines with GI(50) from 5.4 to >25 mu M. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：67 / 77

页数：11

共 43 条

[1]

[Anonymous], 2010, PHARM CROPS, DOI DOI 10.2174/2210290601001010024

[2] STRUCTURE OF TRITERPENE-SAPOGENINS OF AESCULUS-GLABRA [J].