A new dimeric neolignan from Magnolia grandiflora L. seeds

被引：11

作者：

Li, Hong-Mei ^{[1
]}

Zhao, Su-Rong ^{[1
]}

Huo, Qiang ^{[1
]}

Ma, Tao ^{[1
]}

Liu, Hao ^{[1
]}

Lee, Jae Kyoung ^{[2
]}

Hong, Young-Soo ^{[2
]}

Wu, Cheng-Zhu ^{[1
]}

机构：

[1] Bengbu Med Coll, Fac Pharm, Bengbu 233030, Anhui, Peoples R China

[2] KRIBB, Chem Biol Res Ctr, Chungbuk, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2015年 / 38卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Magnolia grandiflora; Neolignans; Cytotoxicity; Apoptosis; PHENOLIC CONSTITUENTS; OBOVATOL; CYCLOOXYGENASE; DISCOVERY;

D O I：

10.1007/s12272-014-0476-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and honokiol (3). The structures of the compounds were determined on the basis of data obtained using NMR and MS. Bishonokiol A (1) showed potent anti-proliferative activities in four human cancer cell lines, with IC50 values ranging from 5.1 to 7.5 A mu M. Additionally, bishonokiol A (1) induced apoptosis, as well as down-regulated the expression of the anti-apoptotic protein Bcl-2 and caspase-3 cleavage in HepG2 cell line.

引用

页码：1066 / 1071

页数：6

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