Copper-Catalyzed Synthesis of Indole-Fused Benzodiazepines

被引：21

作者：

Biswas, Subhasish ^{[1
]}

Batra, Sanjay ^{[1
]}

机构：

[1] Cent Drug Res Inst, CSIR, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 14-15期

关键词：

benzodiazepines; cascade reactions; copper; coupling; indoles; indolo[3,2-b][1,5]benzodiazepines; TUBULIN POLYMERIZATION; INHIBITORS; DERIVATIVES;

D O I：

10.1002/adsc.201100388

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The copper-catalyzed synthesis of indole-fused benzodiazepine via a cascade reaction between 3-halo-1H-indole-2-carbaldehydes and substituted 1,2-phenylenediamines is reported. Reactions with N-Boc-protected indole-aldehydes are found to be more efficient to afford indole[3,2-b][1,5]benzodiazepines.

引用

页码：2861 / 2867

页数：7

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