Structural changes of the brain in rheumatoid arthritis

被引:86
|
作者
Wartolowska, Karolina [1 ,2 ]
Hough, Morgan G. [1 ,2 ]
Jenkinson, Mark [1 ,2 ]
Andersson, Jesper [1 ,2 ]
Wordsworth, B. Paul [3 ,4 ]
Tracey, Irene [1 ,2 ]
机构
[1] John Radcliffe Hosp, Oxford Ctr Funct Magnet Resonance Imaging Brain, Oxford OX3 9DU, England
[2] Univ Oxford, Oxford, England
[3] Nuffield Orthopaed Ctr, NIHR Oxford Musculoskeletal Biomed Res Unit, Oxford OX3 7LD, England
[4] Nuffield Orthopaed Ctr, Botnar Res Ctr, Oxford OX3 7LD, England
来源
ARTHRITIS AND RHEUMATISM | 2012年 / 64卷 / 02期
基金
英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
VOXEL-BASED MORPHOMETRY; TOTAL INTRACRANIAL VOLUME; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; GRAY-MATTER DECREASE; CHRONIC BACK-PAIN; BASAL GANGLIA; CAUDATE-NUCLEUS; MR; FIBROMYALGIA;
D O I
10.1002/art.33326
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To investigate whether structural changes are present in the cortical and subcortical gray matter of the brains of patients with rheumatoid arthritis (RA). Methods. We used two surface-based style morphometry analysis programs and a voxel-based style analysis program to compare high-resolution structural magnetic resonance imaging data obtained for 31 RA patients and 25 age-and sex-matched healthy control subjects. Results. We observed an increase in gray matter content in the basal ganglia of RA patients, mainly in the nucleus accumbens and caudate nucleus. There were no differences in the cortical gray matter. Moreover, patients had a smaller intracranial volume. Conclusion. Our results suggest that RA is associated with changes in the subcortical gray matter rather than with cortical gray matter atrophy. Since the basal ganglia play an important role in motor control as well as in pain processing and in modulating behavior in response to aversive stimuli, we suggest that these changes may result from altered motor control or prolonged pain processing. The differences in brain volume may reflect either generalized atrophy or differences in brain development.
引用
收藏
页码:371 / 379
页数:9
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