Huntington's disease - Genetics lends a hand

被引：1
作者：
Palfi, Stephane [1 ,2 ]
Jarraya, Bechir [1 ,2 ]
机构：
[1] CEA DSV I2BM MIRCen, Fontenay Aux Roses, France
[2] Univ Paris 12, Fac Med, Assistance Publ Hop Paris, Hop Henri Mondor,Serv Neurochirurg, F-94010 Creteil, France
来源：
NATURE | 2008年 / 453卷 / 7197期
关键词：
D O I：
10.1038/nature06365
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A monkey model of Huntington's disease created by gene transfer is only a work in progress. But as a technological feat it offers great promise for fathoming this devastating condition.
引用
收藏
页码：863 / 864
页数：2
相关论文
共 11 条
  • [1] CHRONIC MITOCHONDRIAL ENERGY IMPAIRMENT PRODUCES SELECTIVE STRIATAL DEGENERATION AND ABNORMAL CHOREIFORM MOVEMENTS IN PRIMATES
    BROUILLET, E
    HANTRAYE, P
    FERRANTE, RJ
    DOLAN, R
    LEROYWILLIG, A
    KOWALL, NW
    BEAL, MF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (15) : 7105 - 7109
  • [2] Contributions of non-human primates to neuroscience research
    Capitanio, John P.
    Emborg, Marina E.
    [J]. LANCET, 2008, 371 (9618) : 1126 - 1135
  • [3] Transgenic monkeys produced by retroviral gene transfer into mature oocytes
    Chan, AWS
    Chong, KY
    Martinovich, C
    Simerly, C
    Schatten, G
    [J]. SCIENCE, 2001, 291 (5502) : 309 - 312
  • [4] Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    DiFiglia, M
    Sapp, E
    Chase, KO
    Davies, SW
    Bates, GP
    Vonsattel, JP
    Aronin, N
    [J]. SCIENCE, 1997, 277 (5334) : 1990 - 1993
  • [5] Gutekunst CA, 1999, J NEUROSCI, V19, P2522
  • [6] Multiple pathways contribute to the pathogenesis of Huntington disease
    Li, Shihua
    Li, Xiao-Jiang
    [J]. MOLECULAR NEURODEGENERATION, 2006, 1 (1)
  • [7] A NOVEL GENE CONTAINING A TRINUCLEOTIDE REPEAT THAT IS EXPANDED AND UNSTABLE ON HUNTINGTONS-DISEASE CHROMOSOMES
    MACDONALD, ME
    AMBROSE, CM
    DUYAO, MP
    MYERS, RH
    LIN, C
    SRINIDHI, L
    BARNES, G
    TAYLOR, SA
    JAMES, M
    GROOT, N
    MACFARLANE, H
    JENKINS, B
    ANDERSON, MA
    WEXLER, NS
    GUSELLA, JF
    BATES, GP
    BAXENDALE, S
    HUMMERICH, H
    KIRBY, S
    NORTH, M
    YOUNGMAN, S
    MOTT, R
    ZEHETNER, G
    SEDLACEK, Z
    POUSTKA, A
    FRISCHAUF, AM
    LEHRACH, H
    BUCKLER, AJ
    CHURCH, D
    DOUCETTESTAMM, L
    ODONOVAN, MC
    RIBARAMIREZ, L
    SHAH, M
    STANTON, VP
    STROBEL, SA
    DRATHS, KM
    WALES, JL
    DERVAN, P
    HOUSMAN, DE
    ALTHERR, M
    SHIANG, R
    THOMPSON, L
    FIELDER, T
    WASMUTH, JJ
    TAGLE, D
    VALDES, J
    ELMER, L
    ALLARD, M
    CASTILLA, L
    SWAROOP, M
    [J]. CELL, 1993, 72 (06) : 971 - 983
  • [8] Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates
    Palfi, Stephane
    Brouillet, Emmanuel
    Jarraya, Bechir
    Bloch, Jocelyne
    Jan, Caroline
    Shin, Masahiro
    Conde, Francoise
    Li, Xiao-Jiang
    Aebischer, Patrick
    Hantraye, Philippe
    Deglon, Nicole
    [J]. MOLECULAR THERAPY, 2007, 15 (08) : 1444 - 1451
  • [9] Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm
    Romero, Eliana
    Cha, Guang-Ho
    Verstreken, Patrik
    Ly, Cindy V.
    Hughes, Robert E.
    Bellen, Hugo J.
    Botas, Juan
    [J]. NEURON, 2008, 57 (01) : 27 - 40
  • [10] Sipione S, 2001, MOL NEUROBIOL, V23, P21
12