Paraquat and Parkinson's disease: An overview of the epidemiology and a review of two recent studies

被引:28
作者
Mandel, J. S. [1 ]
Adami, H. -O. [2 ]
Cole, P. [3 ]
机构
[1] Exponent Inc, Menlo Pk, CA 94025 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[3] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA
关键词
Paraquat; Parkinson's disease; Pesticides; Epidemiology; ENVIRONMENTAL RISK-FACTORS; AGRICULTURAL HEALTH; PESTICIDE EXPOSURE; PROXY RESPONDENTS; METAANALYSIS; ASSOCIATION;
D O I
10.1016/j.yrtph.2011.10.004
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
Objective: This paper reviews and evaluates two recent epidemiologic studies focused on pesticides, and in particular, paraquat as a cause of PD. Both studies are derived primarily from the Agricultural Health Study (AHS). A review and evaluation is also provided on the AHS and several additional studies of paraquat and PD. Methods: The methods used to design and conduct the studies and analyze the data are described and evaluated. Results: Studies were inadequately designed and often underpowered with very few exposed individuals. They were not population-based, failed to distinguish incident from prevalent cases, relied on multiple comparisons, and may have reported results selectively. The results across the studies are inconsistent. Conclusions: The inherent difficulties of studying Parkinson's disease in relation to paraquat or other pesticides are well illustrated by these studies. A conclusion regarding these relationships cannot be reached based on the current literature. Further research with higher methodological standards is needed to reach a definitive conclusion. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:385 / 392
页数:8
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