Cancer stem cells: an evolving concept

被引：892

作者：

Nguyen, Long V. ^{[1
,2
]}

Vanner, Robert ^{[3
,4
]}

Dirks, Peter ^{[3
,4
]}

Eaves, Connie J. ^{[1
,2
]}

机构：

[1] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada

[2] Univ British Columbia, Vancouver, BC V5Z 1L3, Canada

[3] Hosp Sick Children, Dept Dev & Stem Cell Biol, Toronto, ON M5G 1X8, Canada

[4] Univ Toronto, Toronto, ON, Canada

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 02期

基金：

加拿大健康研究院;

关键词：

ACUTE MYELOID-LEUKEMIA; BONE-MARROW-CELLS; TUMOR-INITIATING CELLS; IN-VITRO; SELF-RENEWAL; RADIATION SENSITIVITY; HEMATOPOIETIC-CELLS; QUANTITATIVE ASSAY; PROGENITOR CELLS; CHRONIC PHASE;

D O I：

10.1038/nrc3184

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated tissue clones whose continued propagation is vested in a biologically distinct subset of cells that are typically rare. This idea is not new, but has recently gained prominence because of advances in defining normal tissue hierarchies, a greater appreciation of the multistep nature of oncogenesis and improved methods to propagate primary human cancers in immunodeficient mice. As a result we have obtained new insights into why the CSC concept is not universally applicable, as well as a new basis for understanding the complex evolution, phenotypic heterogeneity and therapeutic challenges of many human cancers.

引用

页码：133 / 143

页数：11

共 185 条

[1] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].