Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

被引:23
作者
Lan, Anat [1 ,3 ]
Stein, Daniel [2 ,3 ]
Portillo, Miguel [2 ,3 ]
Toiber, Debra [2 ,3 ]
Kofman, Ora [1 ,3 ]
机构
[1] Ben Gurion Univ Negev, Dept Psychol, POB 653, Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Dept Life Sci, POB 653, Beer Sheva, Israel
[3] Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, POB 653, Beer Sheva, Israel
基金
以色列科学基金会;
关键词
Chlorpyrifos; Social behavior; Prenatal exposure; Organophosphate pesticides; Oxytocin; ORGANOPHOSPHATE PESTICIDE EXPOSURE; DEVELOPMENTAL NEUROTOXICITY; NEURODEVELOPMENTAL DISORDERS; RESIDENTIAL PROXIMITY; POSTNATAL EXPOSURE; GENE-EXPRESSION; MOUSE MODELS; OXYTOCIN; CHILDREN; SEX;
D O I
10.1186/s12993-019-0153-3
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
BackgroundSigns of pervasive developmental disorder and social deficits were reported in toddlers and children whose mothers were exposed to organophosphate pesticides during pregnancy. Deficits in social preference were reported in adult male mice exposed to chlorpyrifos on gestational days 12-15. This study aimed (a) to test the hypothesis that adult female and male mice that were exposed prenatally to subtoxic doses of chlorpyrifos would be impaired in social behavior and (b) to determine if prenatal chlorpyrifos altered the expression of transcripts for oxytocin in the hypothalamus. Pregnant mice were treated by gavage with corn oil vehicle or 2.5mg/kg or 5mg/kg of CPF on gestational days 12-15. Social preference, social and non-social conditioned place preference tasks were tested in adults. Expression of oxytocin transcripts in hypothalamus was measured by qPCR.ResultsChlorpyrifos (5mg/kg on GD 12-15) reduced the innate preference for a conspecific in a dose and sex dependent manner. Adult males exposed prenatally to 5mg/kg CPF showed a reduction in social preference. Socially conditioned place preference was impaired in offspring of dams treated with either dose of CPF. Non-social appetitive place conditioning was impaired in offspring of dams exposed to 2.5mg/kg, but not to 5mg/kg chlorpyrifos. Prenatal chlorpyrifos treatment did not alter the expression of the oxytocin mRNA in the hypothalamus, although expression was significantly lower in females.ConclusionsPrenatal chlorpyrifos induced innate and learned social deficits and non-specific conditioning deficits in adult mice in a sex-dependent manner. Males showed specific social deficits following the higher dose whereas both males and females showed a more generalized conditioning deficit following the intermediate dose.
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页数:9
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共 56 条
  • [11] Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
    Doelen, Guel
    Darvishzadeh, Ayeh
    Huang, Kee Wui
    Malenka, Robert C.
    [J]. NATURE, 2013, 501 (7466) : 179 - +
  • [12] Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort
    Engel, Stephanie M.
    Berkowitz, Gertrud S.
    Barr, Dana B.
    Teitelbaum, Susan L.
    Siskind, Jodi
    Meisel, Stefanie J.
    Wetmur, James G.
    Wolff, Mary S.
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 165 (12) : 1397 - 1404
  • [13] Prenatal Exposure to Organophosphates, Paraoxonase 1, and Cognitive Development in Childhood
    Engel, Stephanie M.
    Wetmur, James
    Chen, Jia
    Zhu, Chenbo
    Barr, Dana Boyd
    Canfield, Richard L.
    Wolff, Mary S.
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2011, 119 (08) : 1182 - 1188
  • [14] Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children
    Eskenazi, Brenda
    Marks, Amy R.
    Bradman, Asa
    Harley, Kim
    Barr, Dana B.
    Johnson, Caroline
    Morga, Norma
    Jewell, Nicholas A.
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2007, 115 (05) : 792 - 798
  • [15] Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes
    Furlong, Melissa A.
    Herring, Amy
    Buckley, Jessie P.
    Goldman, Barbara D.
    Daniels, Julie L.
    Engel, Lawrence S.
    Wolff, Mary S.
    Chen, Jia
    Wetmur, Jim
    Barr, Dana Boyd
    Engel, Stephanie M.
    [J]. ENVIRONMENTAL RESEARCH, 2017, 158 : 737 - 747
  • [16] Prenatal exposure to organophosphate pesticides and reciprocal social behavior in childhood
    Furlong, Melissa A.
    Engel, Stephanie M.
    Barr, Dana Boyd
    Wolff, Mary S.
    [J]. ENVIRONMENT INTERNATIONAL, 2014, 70 : 125 - 131
  • [17] The effects of long-term estradiol treatment on social behavior and gene expression in adult female rats
    Garcia, Alexandra N.
    Bezner, Kelsey
    Depena, Christina
    Yin, Weiling
    Gore, Andrea C.
    [J]. HORMONES AND BEHAVIOR, 2017, 87 : 145 - 154
  • [18] Residential proximity to agricultural fumigant use and respiratory health in 7-year old children
    Gunier, Robert B.
    Raanan, Rachel
    Castorina, Rosemary
    Holland, Nina T.
    Harley, Kim G.
    Balmes, John R.
    Fouquette, Laura
    Eskenazi, Brenda
    Bradman, Asa
    [J]. ENVIRONMENTAL RESEARCH, 2018, 164 : 93 - 99
  • [19] Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism
    Hallmayer, Joachim
    Cleveland, Sue
    Torres, Andrea
    Phillips, Jennifer
    Cohen, Brianne
    Torigoe, Tiffany
    Miller, Janet
    Fedele, Angie
    Collins, Jack
    Smith, Karen
    Lotspeich, Linda
    Croen, Lisa A.
    Ozonoff, Sally
    Lajonchere, Clara
    Grether, Judith K.
    Risch, Neil
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2011, 68 (11) : 1095 - 1102
  • [20] Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies
    Harley, Kim G.
    Engel, Stephanie M.
    Vedar, Michelle G.
    Eskenazi, Brenda
    Whyatt, Robin M.
    Lanphear, Bruce P.
    Bradman, Asa
    Rauh, Virginia A.
    Yolton, Kimberly
    Hornung, Richard W.
    Wetmur, James G.
    Chen, Jia
    Holland, Nina T.
    Barr, Dana Boyd
    Perera, Frederica P.
    Wolff, Mary S.
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2016, 124 (07) : 1084 - 1092