Two novel promoters in the upstream regulatory region of human papillomavirus type 31b are negatively regulated by epithelial differentiation

被引：30

作者：

Ozbun, MA

Meyers, C ^{[1
]}

机构：

[1] Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA

[2] Univ New Mexico, Sch Med, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 04期

关键词：

D O I：

10.1128/JVI.73.4.3505-3510.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Organotypic cultures support the stratification and differentiation of keratinocytes and the human papillomavirus (HPV) life cycle. We report transcription from four novel promoters in the HPV31b upstream regulatory region during the viral life cycle in organotypic cultures. Promoter initiation was not differentiation dependent; two promoters were down-regulated upon epithelial differentiation.

引用

页码：3505 / 3510

页数：6

共 26 条

[1] BOVINE PAPILLOMAVIRUS E2 TRANS-ACTIVATING GENE-PRODUCT BINDS TO SPECIFIC SITES IN PAPILLOMAVIRUS DNA
ANDROPHY, EJ
LOWY, DR
SCHILLER, JT
[J]. NATURE, 1987, 325 (6099) : 70 - 73
[2] DIFFERENTIAL PROMOTER UTILIZATION BY THE BOVINE PAPILLOMAVIRUS IN TRANSFORMED-CELLS AND PRODUCTIVELY INFECTED WART TISSUES
BAKER, CC
HOWLEY, PM
[J]. EMBO JOURNAL, 1987, 6 (04) : 1027 - 1035
[3] AMPLIFICATION OF HUMAN PAPILLOMAVIRUS GENOMES INVITRO IS DEPENDENT ON EPITHELIAL DIFFERENTIATION
BEDELL, MA
HUDSON, JB
GOLUB, TR
TURYK, ME
HOSKEN, M
WILBANKS, GD
LAIMINS, LA
[J]. JOURNAL OF VIROLOGY, 1991, 65 (05) : 2254 - 2260
[4] Conaway, 1994, TRANSCRIPTION MECHAN, P63
[5] TRANSCRIPTIONAL REGULATION OF THE HUMAN PAPILLOMAVIRUS-16 E6-E7 PROMOTER BY A KERATINOCYTE-DEPENDENT ENHANCER, AND BY VIRAL E2 TRANSACTIVATOR AND REPRESSOR GENE-PRODUCTS - IMPLICATIONS FOR CERVICAL CARCINOGENESIS
CRIPE, TP
HAUGEN, TH
TURK, JP
TABATABAI, F
SCHMID, PG
DURST, M
GISSMANN, L
ROMAN, A
TUREK, LP
[J]. EMBO JOURNAL, 1987, 6 (12) : 3745 - 3753
[6] ACCUMULATION OF RNA HOMOLOGOUS TO HUMAN PAPILLOMAVIRUS TYPE-16 OPEN READING FRAMES IN GENITAL PRECANCERS
CRUM, CP
NUOVO, G
FRIEDMAN, D
SILVERSTEIN, SJ
[J]. JOURNAL OF VIROLOGY, 1988, 62 (01) : 84 - 90
[7] THE UPSTREAM REGULATORY REGION OF THE HUMAN PAPILLOMA VIRUS-16 CONTAINS AN E2-PROTEIN-INDEPENDENT ENHANCER WHICH IS SPECIFIC FOR CERVICAL-CARCINOMA CELLS AND REGULATED BY GLUCOCORTICOID HORMONES
GLOSS, B
BERNARD, HU
SEEDORF, K
KLOCK, G
[J]. EMBO JOURNAL, 1987, 6 (12) : 3735 - 3743
[8] NUCLEOTIDE-SEQUENCE OF HUMAN PAPILLOMAVIRUS TYPE-31 - A CERVICAL NEOPLASIA-ASSOCIATED VIRUS
GOLDSBOROUGH, MD
DISILVESTRE, D
TEMPLE, GF
LORINCZ, AT
[J]. VIROLOGY, 1989, 171 (01) : 306 - 311
[9] HOWLEY PM, 1996, PAPILLOMAVIRINAE VIR, P2045
[10] HUMAN PAPILLOMAVIRUS TYPE 31B LATE GENE-EXPRESSION IS REGULATED THROUGH PROTEIN-KINASE C-MEDIATED CHANGES IN RNA PROCESSING
HUMMEL, M
LIM, HB
LAIMINS, LA
[J]. JOURNAL OF VIROLOGY, 1995, 69 (06) : 3381 - 3388

← 1 2 3 →