Controlled cell adhesion on PEG-based switchable surfaces

被引：334
作者：
Wischerhoff, Erik [3 ]
Uhlig, Katja [2 ]
Lankenau, Andreas [2 ]
Boerner, Hans G. [4 ]
Laschewsky, Andre [1 ]
Duschl, Claus [2 ]
Lutz, Jean-Francois [3 ]
机构：
[1] Univ Potsdam, D-14476 Potsdam, Germany
[2] Fraunhofer Inst Biomed Engn, D-14476 Potsdam, Germany
[3] Fraunhofer Inst Appl Polymer Res, D-14476 Potsdam, Germany
[4] Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 30期
关键词：
biotechnology; cell adhesion; materials science; polymers; surface chemistry;
D O I：
10.1002/anie.200801202
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A wash and brush up: Thermoresponsive and biocompatible oligo(ethylene glycol)-based copolymers enable the control of cell adhesion on planar gold substrates. While at physiological temperature, the polymer brushes are collapsed and enable fibroblast adhesion and cultivation, at room temperature, the now hydrated oligo(ethylene glycol) segments become cell-repellent, thus allowing cell harvesting under mild conditions (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5666 / 5668
页数：3
相关论文
共 59 条
[31]   Surface-initiated, atom transfer radical polymerization of oligo(ethylene glycol) methyl ether methacrylate and subsequent click chemistry for bioconjugation [J].
Lee, Bong Soo ;
Lee, Jungkyu K. ;
Kim, Wan-Joong ;
Jung, Young Hwan ;
Sim, Sang Jun ;
Lee, Jeewon ;
Choi, Insung S. .
BIOMACROMOLECULES, 2007, 8 (02) :744-749
[32]   Thermosensitive hairy hybrid nanoparticles synthesized by surface-initiated atom transfer radical polymerization [J].
Li, DJ ;
Jones, GL ;
Dunlap, JR ;
Hua, FJ ;
Zhao, B .
LANGMUIR, 2006, 22 (07) :3344-3351
[33]   Polymerization of oligo(ethylene glycol) (meth)acrylates: Toward new generations of smart biocompatible materials [J].
Lutz, Jean-Francois .
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2008, 46 (11) :3459-3470
[34]   Biocompatible, thermoresponsive, and biodegradable:: Simple preparation of "all-in-one" biorelevant polymers [J].
Lutz, Jean-Francois ;
Andrieu, Julien ;
Uezguen, Senta ;
Rudolph, Carsten ;
Agarwal, Seema .
MACROMOLECULES, 2007, 40 (24) :8540-8543
[35]   About the phase transitions in aqueous solutions of thermoresponsive copolymers and hydrogels based on 2-(2-methoxyethoxy)ethyl methacrylate and oligo(ethylene glycol) methacrylate [J].
Lutz, Jean-Francois ;
Weichenhan, Katja ;
Akdemir, Oezgur ;
Hoth, Ann .
MACROMOLECULES, 2007, 40 (07) :2503-2508
[36]   Point by point comparison of two thermosensitive polymers exhibiting a similar LCST:: Is the age of poly(NIPAM) over? [J].
Lutz, Jean-Francois ;
Akdemir, Oezguer ;
Hoth, Ann .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (40) :13046-13047
[37]   Preparation of ideal PEG analogues with a tunable thermosensitivity by controlled radical copolymerization of 2-(2-methoxyethoxy)ethyl methacrylate and oligo(ethylene glycol) methacrylate [J].
Lutz, JF ;
Hoth, A .
MACROMOLECULES, 2006, 39 (02) :893-896
[38]   Non-fouling oligo(ethylene glycol)-functionalized polymer brushes synthesized by surface-initiated atom transfer radical polymerization [J].
Ma, HW ;
Hyun, JH ;
Stiller, P ;
Chilkoti, A .
ADVANCED MATERIALS, 2004, 16 (04) :338-+
[39]   Hydration changes of poly(2-(2-methoxyethoxy)ethyl methacrylate) during thermosensitive phase separation in water [J].
Maeda, Yasushi ;
Kubota, Tomoyuki ;
Yamauchi, Hideo .
LANGMUIR, 2007, 23 (22) :11259-11265
[40]   Prevention of protein adsorption by tethered poly(ethylene oxide) layers: Experiments and single-chain mean-field analysis [J].
McPherson, T ;
Kidane, A ;
Szleifer, I ;
Park, K .
LANGMUIR, 1998, 14 (01) :176-186
123456