Near-Infrared Light-Excited Reactive Oxygen Species Generation by Thulium Oxide Nanoparticles

被引:40
作者
Duosiken, Dida [1 ]
Yang, Ruihao [1 ]
Dai, Yingfan [1 ]
Marfavi, Zeinab [1 ]
Lv, Quanjie [1 ]
Li, Hanyin [1 ]
Sun, Kang [1 ]
Tao, Ke [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China
基金
中国国家自然科学基金;
关键词
UP-CONVERSION; PHOTODYNAMIC THERAPY; NANOCRYSTALS; INTEGRINS; CANCER;
D O I
10.1021/jacs.1c11704
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Exploring materials that can absorb near-infrared (NIR) light to produce reactive oxygen species (ROS) is necessary for many fields. Herein we show that thulium oxide nanoparticles are viable for NIR-stimulated ROS generation. This property may be related to the unique energy levels, large absorption cross section, low fluorescence emission, and similar to 10(-3) s lifetime of the H-3(4) state of Tm ions. We further demonstrate the impact of these nanoparticles on photodynamic therapy (PDT), in which impressive tumor inhibition was recorded after exposure to either a broadband halogen lamp or an 808 nm laser. Our results may provide insight into the areas of photocatalysis, pollution treatment, and fine chemical synthesis.
引用
收藏
页码:2455 / 2459
页数:5
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