Leishmania Resistance to Miltefosine Associated with Genetic Marker

被引：71

作者：

Cojean, Sandrine ^{[1
]}

Houze, Sandrine ^{[2
]}

Haouchine, Djamel ^{[2
]}

Huteau, Francoise

Lariven, Sylvie ^{[3
]}

Hubert, Veronique ^{[2
]}

Michard, Florence ^{[3
]}

Bories, Christian

Pratlong, Francine ^{[4
]}

Le Bras, Jacques ^{[2
]}

Loiseau, Philippe Marie

Matheron, Sophie ^{[3
]}

机构：

[1] Univ Paris 11, UMR CNRS BioCIS 8076, Grp Chimiotherapie Antiparasitaire, F-92290 Chatenay Malabry, France

[2] Paris Descartes Univ, Paris, France

[3] Paris Diderot Univ, Paris, France

[4] Univ Montpellier, F-34059 Montpellier, France

来源：

EMERGING INFECTIOUS DISEASES | 2012年 / 18卷 / 04期

关键词：

DONOVANI PROMASTIGOTES; TRANSPORTER; STAGE; DRUG;

D O I：

10.3201/eid1804.110841

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：704 / 706

页数：3

共 8 条

[1]

Mbongo N, 1998, ANTIMICROB AGENTS CH, V42, P352

[2] Mechanisms of experimental resistance of Leishmania to miltefosine:: Implications for clinical use [J].

Perez-Victoria, F. Javier ;

Sanchez-Canete, Maria P. ;

Seifert, Karin ;

Croft, Simon L. ;

Sundar, Shyam ;

Castanys, Santiago ;

Gamarro, Francisco .

DRUG RESISTANCE UPDATES, 2006, 9 (1-2) :26-39

[3] Functional cloning of the miltefosine transporter -: A novel P-type phospholipid translocase from Leishmania involved in drug resistance [J].

Pérez-Victoria, FJ ;

Gamarro, F ;

Ouellette, M ;

Castanys, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (50) :49965-49971

[4] Low Plasma Membrane Expression of the Miltefosine Transport Complex Renders Leishmania braziliensis Refractory to the Drug [J].

Sanchez-Canete, Maria P. ;

Carvalho, Luis ;

Perez-Victoria, F. Javier ;

Gamarro, Francisco ;

Castanys, Santiago .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (04) :1305-1313

[5] Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine) [J].

Seifert, K ;

Matu, S ;

Pérez-Victoria, FJ ;

Castanys, S ;

Gamarro, F ;

Croft, SL .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2003, 22 (04) :380-387

[6] Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo [J].

Seifert, Karin ;

Perez-Victoria, F. Javier ;

Stettler, Marianne ;

Sanchez-Canete, Maria P. ;

Castanys, Santiago ;

Gamarro, Francisco ;

Croft, Simon L. .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2007, 30 (03) :229-235

[7] In Vitro Susceptibilities of Leishmania donovani Promastigote and Amastigote Stages to Antileishmanial Reference Drugs: Practical Relevance of Stage-Specific Differences [J].

Vermeersch, Marieke ;

da Luz, Raquel Inocencio ;

Tote, Kim ;

Timmermans, Jean-Pierre ;

Cos, Paul ;

Maes, Louis .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (09) :3855-3859

[8] Selection of the most promising 2-substituted quinoline as antileishmanial candidate for clinical trials [J].

Vieira, Nashira Campos ;

Herrenknecht, Christine ;

Vacus, Joel ;

Fournet, Alain ;

Bories, Christian ;

Figadere, Bruno ;

Espindola, Laila Salmen ;

Loiseau, Philippe M. .

BIOMEDICINE & PHARMACOTHERAPY, 2008, 62 (10) :684-689

← 1 →