Pralatrexate injection for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma

被引：9

作者：

Jennifer, Zhao C. ^{[1
]}

Sara Mohamed, Jaszczur ^{[1
]}

Salma, Afifi ^{[1
]}

Francine, Foss ^{[2
]}

机构：

[1] Yale New Haven Med Ctr, Dept Pharm, 20 York St, New Haven, CT 06504 USA

[2] Yale Univ, Sch Med, Hematol & Bone Marrow Transplantat, New Haven, CT USA

来源：

EXPERT REVIEW OF HEMATOLOGY | 2020年 / 13卷 / 06期

关键词：

Pralatrexate; relapsed or refractory; peripheral T-cell lymphoma; folate antagonist; PROPEL; PHASE-II; NON-HODGKINS; SINGLE-AGENT; ROMIDEPSIN; TRANSPLANTATION; DEXAMETHASONE; METHOTREXATE; GEMCITABINE; EXPRESSION; SUPERIOR;

D O I：

10.1080/17474086.2020.1756257

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Peripheral T cell lymphomas (PTCL) are a heterogenous group of lymphoproliferative disorders which are generally not curable with conventional chemotherapy and associated with inferior outcomes. Pralatrexate is a novel folate analog, the first FDA approved drug) for the treatment of relapsed/refractory (R/R) PTCL. Areas covered: This paper provides a comprehensive review of PubMed literature describing the use of pralatrexate in R/R peripheral T-cell lymphoma. Pharmacokinetics and mechanism of action of pralatrexate are discussed as well as its clinical efficacy and safety in comparison to other agents available in R/R PTCL. Expert opinion: Pralatrexate is an active agent in relapsed/refractory PTCL with lower response rates seen in patients with angioimmunoblastic T cell lymphomas. Mucositis is the most frequently observed adverse event and this can be mitigated by the use of leucovorin along with cyanocobalamin and folic acid.

引用

页码：577 / 583

页数：7

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