Hormone Levels in Pregnancy and Subsequent Risk of Maternal Breast and Ovarian Cancer: A Systematic Review

被引:5
|
作者
Iqbal, Javaid [1 ]
Kahane, Alyssa [2 ]
Park, Alison L. [3 ]
Huang, Tianhua [4 ,5 ]
Meschino, Wendy S. [4 ,6 ]
Ray, Joel G. [3 ]
机构
[1] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[2] Univ Ottawa, Fac Med, Ottawa, ON, Canada
[3] Univ Toronto, St Michaels Hosp, Toronto, ON, Canada
[4] North York Gen Hosp, Genet Program, Toronto, ON, Canada
[5] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada
[6] Univ Toronto, Dept Paediat, Toronto, ON, Canada
关键词
Pregnancy; hormones; risk; epidemiology; breast cancer; ovarian cancer; HUMAN CHORIONIC-GONADOTROPIN; SEX STEROIDS; REPRODUCTIVE FACTORS; SERUM;
D O I
10.1016/j.jogc.2018.03.133
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: Some maternal hormone levels in pregnancy are associated with a higher risk of breast and ovarian cancer. This study systematically assessed the association between blood hormone levels measured in pregnancy and future risk of these cancers. Methods: Two reviewers independently conducted a literature search of MEDLINE and EMBASE databases from January 1970 to August 2017. Studies were included that measured one or more serum hormone levels in pregnancy and later assessed for cancer. Cancer outcomes were considered by cancer type, each in relation to a specific maternal hormone. Results: Eleven studies were included, comprising a total of 57 967 women. The interval between pregnancy and cancer onset varied from 4.1 to 20.5 years. Elevated serum chorionic gonadotropin (two of four studies) and alpha fetoprotein (two of three studies) were each associated with a lower risk of maternal breast cancer, whereas elevated estrone levels suggested a higher risk (one of three studies). Elevated testosterone (one of one study) and androstenedione (one of one study) were each associated with a significantly greater risk of sex-cord stromal ovarian tumours. Higher serum 17-hydroxyprogesterone was associated with an increased risk of sex-cord stromal (one of one study) and epithelial (one of one study) ovarian cancer. Conclusion: Observational studies suggest some degree of association between serum hormones measured in pregnancy and a woman's future risk of breast and ovarian cancer. More data are needed to determine sufficiently whether certain blood hormone levels measured in pregnancy are predictive of future cancer risk. Copyright (C) 2019 The Society of Obstetricians and Gynaecologists of Canada/La Societe des obstetriciens et gynecologues du Canada. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:217 / 222
页数:6
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