Umbilical cord mesenchymal stem cell-derived exosomes alleviate collagen-induced arthritis by balancing the population of Th17 and regulatory T cells

被引：17
|
作者：
Fu, Yanxia [1 ,2 ]
Li, Jun [3 ]
Zhang, Ziyu [2 ]
Ren, Fangli [2 ]
Wang, Yinyin [2 ]
Jia, Huihui [2 ]
Liu, Jihe [4 ]
Chang, Zhijie [2 ]
机构：
[1] Capital Med Univ, Dept Biochem & Mol Biol, Beijing, Peoples R China
[2] Tsinghua Univ, Ctr Synthet & Syst Biol, State Key Lab Membrane Biol, Sch Med,Inst Precis Med, Beijing, Peoples R China
[3] TsCell Biotech Inc, Beijing, Peoples R China
[4] Beijing 2 Middle Sch, Beijing, Peoples R China
来源：
FEBS LETTERS | 2022年 / 596卷 / 20期
关键词：
exosome; immunoregulation; rheumatoid arthritis; umbilical cord MSCs; RHEUMATOID-ARTHRITIS; AUTOIMMUNE;
D O I：
10.1002/1873-3468.14460
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Exosomes released by mesenchymal stem cells (MSCs) are thought to function as extensions of the MSCs. However, it remains unclear whether exosomes derived from human umbilical cord MSCs (HUMSCs) possess immunoregulatory functions in rheumatoid arthritis. We report that when mice with collagen-induced arthritis were injected with exosomes derived from HUMSC (HUMSC-Exo), their paws became less swollen, and they had lower serum pro-inflammatory cytokine and anti-collagen IgG levels, and decreased synovial hyperplasia. The HUMSC-Exo appeared to restore the balance between Th17 and Treg cells, and this effect was accompanied by reduced IL-17 and enhanced TGF-beta and IL-10 levels. These findings suggest that HUMSC-Exo function as important regulator of the balance between Th1/Th17 and Treg cells during immune and inflammatory responses.
引用
收藏
页码：2668 / 2677
页数：10
相关论文
共 50 条
  • [1] Gingival mesenchymal stem cell-derived exosomes are immunosuppressive in preventing collagen-induced arthritis
    Tian, Xiaohong
    Wei, Wumei
    Cao, Yue
    Ao, Tianrang
    Huang, Feng
    Javed, Rabia
    Wang, Xiaohong
    Fan, Jun
    Zhang, Yanhui
    Liu, Yanying
    Lai, Laijun
    Ao, Qiang
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2022, 26 (03) : 693 - 708
  • [2] GdX/UBL4A-knockout mice resist collagen-induced arthritis by balancing the population of Th1/Th17 and regulatory T cells
    Fu, Yanxia
    Liu, Sihan
    Wang, Yinyin
    Ren, Fangli
    Fan, Xuanzi
    Liang, Jiao
    Liu, Chunxiao
    Li, Jun
    Ju, Yanfang
    Chang, Zhijie
    FASEB JOURNAL, 2019, 33 (07): : 8375 - 8385
  • [3] Adoptive Transfer of Human Gingiva-Derived Mesenchymal Stem Cells Ameliorates Collagen-Induced Arthritis via Suppression of Th1 and Th17 Cells and Enhancement of Regulatory T Cell Differentiation
    Chen, Maogen
    Su, Wenru
    Lin, Xiaohong
    Guo, Zhiyong
    Wang, Julie
    Zhang, Qunzhou
    Brand, David
    Ryffel, Bernhard
    Huang, Jiefu
    Liu, Zhongmin
    He, Xiaoshun
    Le, Anh D.
    Zheng, Song Guo
    ARTHRITIS AND RHEUMATISM, 2013, 65 (05): : 1181 - 1193
  • [4] Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles ameliorate collagen-induced arthritis via immunomodulatory T lymphocytes
    Xu, Ke
    Ma, Dan
    Zhang, Gailian
    Gao, Jinfang
    Su, Yazhen
    Liu, Sumiao
    Liu, Yang
    Han, Jian
    Tian, Min
    Wei, Chun
    Zhang, Liyun
    MOLECULAR IMMUNOLOGY, 2021, 135 : 36 - 44
  • [5] Regulation of the Th17/Treg balance by human umbilical cord mesenchymal stem cell-derived exosomes protects against acute experimental colitis
    Heidari, Neda
    Abbasi-Kenarsari, Hajar
    Namaki, Saeed
    Baghaei, Kaveh
    Zali, Mohammad Reza
    Mirsanei, Zahra
    Hashemi, Seyed Mahmoud
    EXPERIMENTAL CELL RESEARCH, 2022, 419 (01)
  • [6] Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Rescue Testicular Aging
    Luo, Peng
    Chen, Xuren
    Gao, Feng
    Xiang, Andy Peng
    Deng, Chunhua
    Xia, Kai
    Gao, Yong
    BIOMEDICINES, 2024, 12 (01)
  • [7] Sinomenine suppresses collagen-induced arthritis by reciprocal modulation of regulatory T cells and Th17 cells in gut-associated lymphoid tissues
    Tong, Bei
    Yu, Juntao
    Wang, Ting
    Dou, Yannong
    Wu, Xin
    Kong, Lingyi
    Dai, Yue
    Xia, Yufeng
    MOLECULAR IMMUNOLOGY, 2015, 65 (01) : 94 - 103
  • [8] Myeloid-derived suppressor cells are proinflammatory and regulate collagen-induced arthritis through manipulating Th17 cell differentiation
    Zhang, Hui
    Wang, Shuang
    Huang, Yuefang
    Wang, Hongyue
    Zhao, Jijun
    Gaskin, Felicia
    Yang, Niansheng
    Fu, Shu Man
    CLINICAL IMMUNOLOGY, 2015, 157 (02) : 175 - 186
  • [9] Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis
    Deng, Shaohua
    Xi, Yebin
    Wang, Hong
    Hao, Jing
    Niu, Xiaoyin
    Li, Weiyi
    Tao, Yue
    Chen, Guangjie
    CELLULAR IMMUNOLOGY, 2010, 265 (02) : 105 - 110
  • [10] Glucocorticoid-Induced Leucine Zipper Governs the Therapeutic Potential of Mesenchymal Stem Cells by Inducing a Switch From Pathogenic to Regulatory Th17 Cells in a Mouse Model of Collagen-Induced Arthritis
    Luz-Crawford, P.
    Tejedor, G.
    Mausset-Bonnefont, A. L.
    Beaulieu, E.
    Morand, E. F.
    Jorgensen, C.
    Noel, D.
    Djouad, F.
    ARTHRITIS & RHEUMATOLOGY, 2015, 67 (06) : 1514 - 1524
12345