Reversing histone methylation

被引：376

作者：

Bannister, AJ

Kouzarides, T

机构：

[1] Gurdon Inst, Cambridge CB2 1QN, England

[2] Dept Pathol, Cambridge CB2 1QN, England

来源：

NATURE | 2005年 / 436卷 / 7054期

关键词：

D O I：

10.1038/nature04048

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Histones package DNA, and post-translational modifications of histones can regulate access to DNA. Until recently, histone methylation - unlike all other histone modifications - was considered a permanent mark. The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking on the unique nature of histone methylation, and substantially increases the complexity of histone modification pathways.

引用

页码：1103 / 1106

页数：4

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