OXIDATION OF FURSEMIDE BY PERMANGANATE IN AQUEOUS ALKALINE MEDIUM. A KINETIC STUDY

被引：0
|
作者：
Angadi, M. A. [1 ]
Tuwar, S. M. [1 ]
机构：
[1] Karnatak Sci Coll, Dept Chem, Dharwad 580001, Karnataka, India
来源：
OXIDATION COMMUNICATIONS | 2011年 / 34卷 / 03期
关键词：
kinetics; oxidation; fursemide; permanganate; ACID; MECHANISM; ARGININE;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Kinetics of oxidation of fursemide by alkaline permanganate was studied spectrophotometrically. Reaction was found to be first order in [permanganate] and fractional order in [fursemide]. The kinetics was independent on [OH(-)]. The added salt did not alter the rate of reaction. The oxidation products of fursemide were identified as furfuraldehyde and 4-chloro-2-amino-5-(amino-sulphonyl) benzoic acid. A suitable mechanism based on proton abstraction from the a-carbon atom of furfuryl moiety by permanganate was proposed as given below permanganate + fursemide (sic) complex complex (sic) free radical + manganate and other fast steps. Rate law was derived and verified. The equilibrium constant, K, and rate constant of the slow step, k, are evaluated and used to calculate the experimental rate constants.
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页码：555 / 565
页数：11
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