共 16 条
Cerebral Toxoplasmosis as an Uncommon Complication of Biologic Therapy for Rheumatoid Arthritis: Case Report and Review of the Literature
被引:0
作者:

de Almeida, Goncalo Borges
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Sao Jose, Dept Neuroradiol, P-1150199 Lisbon, Portugal Hosp Sao Jose, Dept Neuroradiol, P-1150199 Lisbon, Portugal

Cristovao, Miguel
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Sao Jose, Dept Pathol, P-1150199 Lisbon, Portugal Hosp Sao Jose, Dept Neuroradiol, P-1150199 Lisbon, Portugal

Pontinha, Carlos
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Sao Jose, Dept Pathol, P-1150199 Lisbon, Portugal Hosp Sao Jose, Dept Neuroradiol, P-1150199 Lisbon, Portugal

Januario, Goncalo
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Sao Jose, Dept Neurosurg, P-1150199 Lisbon, Portugal Hosp Sao Jose, Dept Neuroradiol, P-1150199 Lisbon, Portugal
机构:
[1] Hosp Sao Jose, Dept Neuroradiol, P-1150199 Lisbon, Portugal
[2] Hosp Sao Jose, Dept Pathol, P-1150199 Lisbon, Portugal
[3] Hosp Sao Jose, Dept Neurosurg, P-1150199 Lisbon, Portugal
关键词:
cerebral toxoplasmosis;
rheumatoid arthritis;
biologic therapy;
adalimumab;
GONDII INFECTION;
INFLIXIMAB;
D O I:
10.3390/brainsci12081050
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Toxoplasmosis is one of the most common opportunistic infections, mainly reported in patients with acquired immunodeficiency syndrome (AIDS). Patients with rheumatoid arthritis (RA) have also been linked to reactivation of toxoplasmosis due to immunosuppressive treatment, although biologic drugs have seldom been implicated. We present a case of cerebral toxoplasmosis in a 62-year-old female patient with RA after initiation of biologic therapy (adalimumab). The patient had detectable serum IgG antibodies to toxoplasma gondii, was also on chronic treatment with other non-biologic drugs and presented with worsening disorientation, unsteady gait and left hemiparesis. Imaging studies showed a space-occupying lesion in the right basal ganglia with ring-enhancement. Brain biopsy confirmed the diagnosis of toxoplasmosis and the patient was treated with pyrimethamine and sulfadiazine for 6 weeks, showing complete recovery on follow-up. A review of the literature yielded other four case reports of cerebral toxoplasmosis implying biologic drugs; however, data concerning toxoplasmosis serologic testing, prophylaxis and treatment in these patients are lacking. Each case must be carefully evaluated prior to treatment and a high-index of suspicion in seropositive patients is warranted. Since the use of biologic drugs is increasing, further research is needed to establish practical guidelines for seropositive patients receiving immunosuppressive treatment.
引用
收藏
页数:7
相关论文
共 16 条
[1]
Non-viral opportunistic infections in new users of tumour necrosis factor inhibitor therapy: results of the SAfety Assessment of Biologic ThERapy (SABER) Study
[J].
Baddley, John W.
;
Winthrop, Kevin L.
;
Chen, Lang
;
Liu, Liyan
;
Grijalva, Carlos G.
;
Delzell, Elizabeth
;
Beukelman, Timothy
;
Patkar, Nivedita M.
;
Xie, Fenglong
;
Saag, Kenneth G.
;
Herrinton, Lisa J.
;
Solomon, Daniel H.
;
Lewis, James D.
;
Curtis, Jeffrey R.
.
ANNALS OF THE RHEUMATIC DISEASES,
2014, 73 (11)
:1942-1948

Baddley, John W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA
Birmingham VA Med Ctr, Med Serv, Birmingham, AL USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Winthrop, Kevin L.
论文数: 0 引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Chen, Lang
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Liu, Liyan
论文数: 0 引用数: 0
h-index: 0
机构:
Kaiser Permanente No Calif, Div Res, Oakland, CA USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Grijalva, Carlos G.
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Med, Nashville, TN USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Delzell, Elizabeth
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

论文数: 引用数:
h-index:
机构:

Patkar, Nivedita M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Xie, Fenglong
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Saag, Kenneth G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Herrinton, Lisa J.
论文数: 0 引用数: 0
h-index: 0
机构:
Kaiser Permanente No Calif, Div Res, Oakland, CA USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Solomon, Daniel H.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Lewis, James D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Perlman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA

Curtis, Jeffrey R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA
[2]
Epidemiology, Pathophysiology, Diagnosis, and Management of Cerebral Toxoplasmosis
[J].
Elsheikha, Hany M.
;
Marra, Christina M.
;
Zhu, Xing-Quan
.
CLINICAL MICROBIOLOGY REVIEWS,
2020, 34 (01)
:1-28

Elsheikha, Hany M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nottingham, Sch Vet Med & Sci, Fac Med & Hlth Sci, Loughborough, Leics, England Univ Nottingham, Sch Vet Med & Sci, Fac Med & Hlth Sci, Loughborough, Leics, England

Marra, Christina M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA
Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA Univ Nottingham, Sch Vet Med & Sci, Fac Med & Hlth Sci, Loughborough, Leics, England

Zhu, Xing-Quan
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Key Lab Vet Parasitol Gansu Prov, Lanzhou, Gansu, Peoples R China
Shanxi Agr Univ, Coll Vet Med, Taigu, Shanxi, Peoples R China Univ Nottingham, Sch Vet Med & Sci, Fac Med & Hlth Sci, Loughborough, Leics, England
[3]
Detection of Toxoplasma gondii by polymerase chain reaction in cerebrospinal fluid from human immunodeficiency virus-1-infected Japanese patients with focal neurological signs
[J].
Goto, M
;
Takahashi, T
;
Kanda, T
;
Iwamoto, A
.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,
2004, 32 (06)
:665-670

Goto, M
论文数: 0 引用数: 0
h-index: 0
机构: Kanazawa Med Univ, Dept Gen Med, Kahoku, Ishikawa 9200293, Japan

Takahashi, T
论文数: 0 引用数: 0
h-index: 0
机构: Kanazawa Med Univ, Dept Gen Med, Kahoku, Ishikawa 9200293, Japan

Kanda, T
论文数: 0 引用数: 0
h-index: 0
机构: Kanazawa Med Univ, Dept Gen Med, Kahoku, Ishikawa 9200293, Japan

论文数: 引用数:
h-index:
机构:
[4]
Toxoplasmosis of the central nervous system: Manifestations vary with immune responses
[J].
Graham, Alice K.
;
Fong, Crystal
;
Naqvi, Asghar
;
Lu, Jian-Qiang
.
JOURNAL OF THE NEUROLOGICAL SCIENCES,
2021, 420

Graham, Alice K.
论文数: 0 引用数: 0
h-index: 0
机构:
McMaster Univ, Hamilton Gen Hosp, Dept Pathol & Mol Med, Hamilton, ON, Canada McMaster Univ, Hamilton Gen Hosp, Dept Pathol & Mol Med, Hamilton, ON, Canada

Fong, Crystal
论文数: 0 引用数: 0
h-index: 0
机构:
McMaster Univ, Hamilton Gen Hosp, Dept Radiol, Neuroradiol Div, Hamilton, ON, Canada McMaster Univ, Hamilton Gen Hosp, Dept Pathol & Mol Med, Hamilton, ON, Canada

Naqvi, Asghar
论文数: 0 引用数: 0
h-index: 0
机构:
McMaster Univ, Hamilton Gen Hosp, Dept Pathol & Mol Med, Hamilton, ON, Canada McMaster Univ, Hamilton Gen Hosp, Dept Pathol & Mol Med, Hamilton, ON, Canada

Lu, Jian-Qiang
论文数: 0 引用数: 0
h-index: 0
机构:
McMaster Univ, Hamilton Gen Hosp, Dept Pathol & Mol Med, Hamilton, ON, Canada
McMaster Univ, Hamilton Gen Hosp, Neuropathol Sect, Hamilton, ON, Canada McMaster Univ, Hamilton Gen Hosp, Dept Pathol & Mol Med, Hamilton, ON, Canada
[5]
Cerebral Toxoplasmosis in a Rheumatoid Arthritis Patient on Immunosuppressive Therapy
[J].
Hill, Brittany
;
Wyatt, Nicole
;
Ennis, David
.
CUREUS JOURNAL OF MEDICAL SCIENCE,
2020, 12 (06)

Hill, Brittany
论文数: 0 引用数: 0
h-index: 0
机构:
Brookwood Baptist Med Ctr, Internal Med, Birmingham, AL 35209 USA Brookwood Baptist Med Ctr, Internal Med, Birmingham, AL 35209 USA

Wyatt, Nicole
论文数: 0 引用数: 0
h-index: 0
机构:
Brookwood Baptist Med Ctr, Internal Med, Birmingham, AL 35209 USA Brookwood Baptist Med Ctr, Internal Med, Birmingham, AL 35209 USA

Ennis, David
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Infect Dis, Birmingham, AL USA Brookwood Baptist Med Ctr, Internal Med, Birmingham, AL 35209 USA
[6]
Toxoplasmosis seroprevalence in rheumatoid arthritis patients: A systematic review and meta-analysis
[J].
Hosseininejad, Zahra
;
Sharif, Mehdi
;
Sarvi, Shahabeddin
;
Amouei, Afsaneh
;
Hosseini, Seyed Abdollah
;
Chegeni, Tooran Nayeri
;
Anvari, Davood
;
Saberi, Reza
;
Gohardehi, Shaban
;
Mizani, Azadeh
;
Sadeghi, Mitra
;
Daryani, Ahmad
.
PLOS NEGLECTED TROPICAL DISEASES,
2018, 12 (06)

Hosseininejad, Zahra
论文数: 0 引用数: 0
h-index: 0
机构:
Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran
Mazandaran Univ Med Sci, Sch Med, Dept Parasitol, Sari, Iran
Mazandaran Univ Med Sci, Student Res Comm, Sari, Mazandaran, Iran Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran

论文数: 引用数:
h-index:
机构:

Sarvi, Shahabeddin
论文数: 0 引用数: 0
h-index: 0
机构:
Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran
Mazandaran Univ Med Sci, Sch Med, Dept Parasitol, Sari, Iran Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran

论文数: 引用数:
h-index:
机构:

Hosseini, Seyed Abdollah
论文数: 0 引用数: 0
h-index: 0
机构:
Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran
Mazandaran Univ Med Sci, Sch Med, Dept Parasitol, Sari, Iran Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran

Chegeni, Tooran Nayeri
论文数: 0 引用数: 0
h-index: 0
机构:
Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran
Mazandaran Univ Med Sci, Sch Med, Dept Parasitol, Sari, Iran Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran

Anvari, Davood
论文数: 0 引用数: 0
h-index: 0
机构:
Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran
Mazandaran Univ Med Sci, Sch Med, Dept Parasitol, Sari, Iran Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran

Saberi, Reza
论文数: 0 引用数: 0
h-index: 0
机构:
Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran
Mazandaran Univ Med Sci, Sch Med, Dept Parasitol, Sari, Iran Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran

Gohardehi, Shaban
论文数: 0 引用数: 0
h-index: 0
机构:
Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran

论文数: 引用数:
h-index:
机构:

Sadeghi, Mitra
论文数: 0 引用数: 0
h-index: 0
机构:
Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran
Mazandaran Univ Med Sci, Sch Med, Dept Parasitol, Sari, Iran Mazandaran Univ Med Sci, Toxoplasmosis Res Ctr, Sari, Iran

论文数: 引用数:
h-index:
机构:
[7]
Biologic Therapies in Rheumatoid Arthritis and the Risk of Opportunistic Infections: A Meta-analysis
[J].
Kourbeti, Irene S.
;
Ziakas, Panayiotis D.
;
Mylonakis, Eleftherios
.
CLINICAL INFECTIOUS DISEASES,
2014, 58 (12)
:1649-1657

Kourbeti, Irene S.
论文数: 0 引用数: 0
h-index: 0
机构:
Rhode Isl Hosp, Div Infect Dis, Providence, RI 02903 USA
Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA Rhode Isl Hosp, Div Infect Dis, Providence, RI 02903 USA

Ziakas, Panayiotis D.
论文数: 0 引用数: 0
h-index: 0
机构:
Rhode Isl Hosp, Div Infect Dis, Providence, RI 02903 USA
Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA Rhode Isl Hosp, Div Infect Dis, Providence, RI 02903 USA

论文数: 引用数:
h-index:
机构:
[8]
Cerebral Toxoplasmosis
[J].
Lee, Gregory Tse
;
Antelo, Fernando
;
Mlikotic, Anton A.
.
RADIOGRAPHICS,
2009, 29 (04)
:1200-1205

Lee, Gregory Tse
论文数: 0 引用数: 0
h-index: 0
机构:
Harbor UCLA Med Ctr, Dept Radiol, Torrance, CA 90509 USA Harbor UCLA Med Ctr, Dept Radiol, Torrance, CA 90509 USA

Antelo, Fernando
论文数: 0 引用数: 0
h-index: 0
机构:
Harbor UCLA Med Ctr, Dept Pathol, Torrance, CA 90509 USA Harbor UCLA Med Ctr, Dept Radiol, Torrance, CA 90509 USA

Mlikotic, Anton A.
论文数: 0 引用数: 0
h-index: 0
机构:
Harbor UCLA Med Ctr, Dept Radiol, Torrance, CA 90509 USA Harbor UCLA Med Ctr, Dept Radiol, Torrance, CA 90509 USA
[9]
Toxoplasmosis in immunosuppressed patients Unanswered questions
[J].
Lewis, Joseph M.
;
Clifford, Sarah
;
Nsutebu, Emmanuel
.
RHEUMATOLOGY,
2015, 54 (11)
:1939-1940

Lewis, Joseph M.
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Liverpool Univ Hosp, Trop & Infect Dis Unit, Liverpool L7 8XP, Merseyside, England Royal Liverpool Univ Hosp, Trop & Infect Dis Unit, Liverpool L7 8XP, Merseyside, England

Clifford, Sarah
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Liverpool Univ Hosp, Trop & Infect Dis Unit, Liverpool L7 8XP, Merseyside, England Royal Liverpool Univ Hosp, Trop & Infect Dis Unit, Liverpool L7 8XP, Merseyside, England

Nsutebu, Emmanuel
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Liverpool Univ Hosp, Trop & Infect Dis Unit, Liverpool L7 8XP, Merseyside, England Royal Liverpool Univ Hosp, Trop & Infect Dis Unit, Liverpool L7 8XP, Merseyside, England
[10]
Toxoplasmosis
[J].
Montoya, JG
;
Liesenfeld, O
.
LANCET,
2004, 363 (9425)
:1965-1976

Montoya, JG
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin, Inst Infect Med, Dept Med Microbiol & Immunol Infect, D-12203 Berlin, Germany

Liesenfeld, O
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin, Inst Infect Med, Dept Med Microbiol & Immunol Infect, D-12203 Berlin, Germany