Development of a multifunctional gold nanoplatform for combined chemo-photothermal therapy against oral cancer

被引：33

作者：

Liu, Zengying ^{[1
]}

Shi, Jianbo ^{[1
]}

Zhu, Bangshang ^{[2
]}

Xu, Qin ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Natl Clin Res Ctr Oral Dis, Dept Oral & Maxillofacial Head Neck Oncol, Peoples Hosp 9,Sch Med,Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China

[2] Shanghai Jiao Tong Univ, Instrumental Anal Ctr, Shanghai 200240, Peoples R China

来源：

NANOMEDICINE | 2020年 / 15卷 / 07期

关键词：

chemotherapy; doxorubicin; drug-delivery systems; gold nanoparticles; oral cancer; photothermal therapy; CELLULAR UPTAKE; DRUG-DELIVERY; NANOPARTICLES; HYPERTHERMIA; COMBINATION; DOXORUBICIN; RESISTANCE; PH; BIODISTRIBUTION; TRANSPORTERS;

D O I：

10.2217/nnm-2019-0415

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: To design and fabricate a multifunctional drug-delivery nanoplatform for oral cancer therapy. Materials & methods: Polyethylene glycol-stabilized, PDPN antibody (PDPN Ab)- and doxorubicin (DOX)-conjugated gold nanoparticles (AuNPs) were prepared and evaluated for their cytotoxicity and antitumor efficacy in both chemotherapy and photothermal therapy. Results: The obtained (PDPN Ab)-AuNP-DOX system presents low toxicity, a high drug loading capacity and cellular uptake efficiency. Both in vitro and in vivo experiments demonstrate that (PDPN Ab)-AuNP-DOX has enhanced antitumor efficacy. Treatment with (PDPN Ab)-AuNP-DOX combined with laser irradiation exhibits superior antitumor effects. Conclusion: This (PDPN Ab)-AuNP-DOX system may be used as a versatile drug-delivery nanoplatform for targeted and combined chemo-photothermal therapy against oral cancer.

引用

页码：661 / 676

页数：16

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