The circadian clock of Neurospora crassa

被引:169
作者
Baker, Christopher L. [1 ]
Loros, Jennifer J. [1 ,2 ]
Dunlap, Jay C. [1 ,2 ]
机构
[1] Dartmouth Med Sch, Dept Genet, Hanover, NH 03755 USA
[2] Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA
基金
美国国家卫生研究院;
关键词
circadian rhythms; negative feedback; post-translational modification; protein phosphorylation; frequency; white collar; WHITE-COLLAR COMPLEX; INTERLOCKED FEEDBACK LOOPS; LIGHT SIGNAL-TRANSDUCTION; INTERACTING RNA HELICASE; PERIOD GENE-PRODUCT; DROSOPHILA-PERIOD; TEMPERATURE COMPENSATION; TRANSCRIPTION FACTOR; FREQUENCY DETERMINES; BIOLOGICAL CLOCK;
D O I
10.1111/j.1574-6976.2011.00288.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Circadian clocks organize our inner physiology with respect to the external world, providing life with the ability to anticipate and thereby better prepare for major fluctuations in its environment. Circadian systems are widely represented in nearly all major branches of life, except archaebacteria, and within the eukaryotes, the filamentous fungus Neurospora crassa has served for nearly half a century as a durable model organism for uncovering the basic circadian physiology and molecular biology. Studies using Neurospora have clarified our fundamental understanding of the clock as nested positive and negative feedback loops regulated through transcriptional and post-transcriptional processes. These feedback loops are centered on a limited number of proteins that form molecular complexes, and their regulation provides a physical explanation for nearly all clock properties. This review will introduce the basics of circadian rhythms, the model filamentous fungus N. crassa, and provide an overview of the molecular components and regulation of the circadian clock.
引用
收藏
页码:95 / 110
页数:16
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