Coexistence of Fetal Cardiac Malformation and Maternal Drug-Induced Lupus: Is Lamotrigine Safe?

被引：1

作者：

Degirmencioglu, Halil ^{[1
]}

Sari, Fatma N. ^{[2
]}

Dizdar, Evrim Alyamac ^{[2
]}

Say, Birgul ^{[2
]}

Altug, Nahide ^{[3
]}

Uras, Nurdan ^{[2
]}

Canpolat, Fuat E. ^{[2
]}

Oguz, Serife S. ^{[2
]}

机构：

[1] Aydin Matern & Childrens Hosp, Div Neonatol, Efeler Mah,Ataturk Bul 96, Aydin, Turkey

[2] Zekai Tahir Burak Matern Teaching Hosp, Dept Neonatol, Ankara, Turkey

[3] Zekai Tahir Burak Matern Teaching Hosp, Dept Pediat Cardiol, Ankara, Turkey

来源：

AMERICAN JOURNAL OF THERAPEUTICS | 2016年 / 23卷 / 05期

关键词：

Lamotrigine; drug-induced lupus erythematosus; congenital heart disease; newborn; PREGNANCY; COARCTATION; DIAGNOSIS; EPILEPSY; LIFE;

D O I：

10.1097/MJT.0000000000000324

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lamotrigine (LTG) is a widely used second-generation antiepileptic drug for long-term therapy of epileptic patients. Although LTG monotherapy during pregnancy is assumed to be relatively safe, teratogenic effects related to LTG has been reported previously. The presence of fetal malformations and maternal drug-induced lupus erythematosus concurrently in a pregnant women using LTG have not been reported before. We herein report a term infant with coarctation of aorta and ventricular septal defect, who was born to a mother treated with LTG for epilepsy before conception and throughout pregnancy. The mother was diagnosed with drug-induced lupus erythematosus at the 36th gestational week, and the symptoms resolved after discontinuation of the drug. Fetal cardiac anomalies should be searched in mothers who were exposed to LTG during pregnancy.

引用

页码：E1263 / E1265

页数：3