Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients

被引：40
作者：
Sai, Kimie [1 ]
Saito, Yoshiro [2 ]
Sakamoto, Hiromi [3 ]
Shirao, Kuniaki [4 ]
Kurose, Koichi [5 ]
Saeki, Mayumi [6 ]
Ozawa, Shogo [7 ]
Kaniwa, Nahoko [5 ]
Hirohashi, Setsuo [8 ]
Saijo, Nagahiro [9 ]
Sawada, Jun-ichi [2 ]
Yoshida, Teruhiko [3 ]
机构：
[1] Natl Inst Hlth Sci, Div Biosignaling, Setagaya Ku, Tokyo 1588501, Japan
[2] Natl Inst Hlth Sci, Dept Biochem & Immunochem, Setagaya Ku, Tokyo 1588501, Japan
[3] Natl Inst Canc Res, Div Genet, Chuo Ku, Tokyo 1040045, Japan
[4] Natl Canc Ctr, Div Internal Med, Chuo Ku, Tokyo 1040045, Japan
[5] Natl Inst Hlth Sci, Div Med Safety Sci, Setagaya Ku, Tokyo 1588501, Japan
[6] Natl Inst Hlth Sci, Project Team Pharmacogenet, Setagaya Ku, Tokyo 1588501, Japan
[7] Natl Inst Hlth Sci, Div Pharmacol, Setagaya Ku, Tokyo 1588501, Japan
[8] Natl Inst Canc Res, Div Pathol, Chuo Ku, Tokyo 1040045, Japan
[9] Natl Canc Ctr Hosp E, Chiba 2778577, Japan
来源：
CANCER LETTERS | 2008年 / 261卷 / 02期
关键词：
UGT1A1; pharmacogenetics; irinotecan; SN-38;
D O I：
10.1016/j.canlet.2007.11.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent pharmacogenetic studies on irinotecan have revealed the impact of UDP glucuronosyltransferase (UGT) 1A1*28 on severe irinotecan toxicities. Although the clinical role of UGT1A1*6, which is specifically detected in East Asian patients, in irinotecan toxicities is suggested, clear evidence remains limited. To examine the impact of *6, the association of UGT1A1 genotypes with severe irinotecan toxicities was retrospectively investigated in Japanese cancer patients. A significant *6-dependent increase in the incidence of grade 3 or 4 neutropenia was observed in 49 patients on irinotecan mono-therapy (p = 0.012). This study further clarifies the clinical importance of *6 in irinotecan therapy in East Asians. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：165 / 171
页数：7
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