Suzuki-Miyaura cross-coupling of benzylic bromides under microwave conditions

被引：13
|
作者：
McDaniel, Steven W. [1 ]
Keyari, Charles M. [1 ]
Rider, Kevin C. [1 ]
Natale, Nicholas R. [1 ]
Diaz, Philippe [1 ]
机构：
[1] Univ Montana, Core Lab Neuromol Prod, Dept Biomed & Pharmaceut Sci, Missoula, MT 59803 USA
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 43期
关键词：
Suzuki-Miyaura; Cross-coupling; Microwave; Palladium; LATERAL METALATION; ARYLBORONIC ACIDS; ARYL CHLORIDES; TRANSPORTER; ISOXAZOLES; AMINATION; ARYLATION; PARTNERS; CATALYST; RECEPTOR;
D O I：
10.1016/j.tetlet.2011.08.096
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)(2), JohnPhos as the catalyst and ligand, potassium carbonate as base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5656 / 5658
页数：3
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