Miniaturization of a micro-optics array for highly sensitive and parallel detection on an injection moulded lab-on-a-chip

被引：20
|
作者：
Tran Quang Hung [1 ,2 ]
Sun, Yi [1 ]
Poulsen, Carl Esben [1 ]
Than Linh-Quyen [2 ]
Chin, Wai Hoe [2 ]
Dang Duong Bang [2 ]
Wolff, Anders [1 ]
机构：
[1] Tech Univ Denmark, DTU Nanotech, Dept Micro & Nanotechnol, DK-2800 Lyngby, Denmark
[2] Tech Univ Denmark DTU Food, Lab Appl Micro & Nanotechnol LAMINATE, Natl Food Inst, Lyngby, Denmark
来源：
LAB ON A CHIP | 2015年 / 15卷 / 11期
关键词：
FLUORESCENCE MICROSCOPY; PROBES;
D O I：
10.1039/c5lc00176e
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A miniaturised array of supercritical angle fluorescence (SAF) micro-optics embedded in a microfluidic chamber was fabricated by injection moulding. The fabricated chip could enhance the fluorescence signal around 46 times compared to a conventional microscope. Collection of the fluorescence signal from the SAF array is almost independent of the numerical aperture, and the limit of detection was improved 36-fold using a simple and inexpensive optical detection system.
引用
收藏
页码：2445 / 2451
页数：7
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