Viral effects on antigen processing

被引：34

作者：

Miller, DM ^{[1
]}

Sedmak, DD ^{[1
]}

机构：

[1] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(99)80017-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viruses have evolved numerous mechanisms that modulate MHC-mediated antigen presentation, which in turn protect infected cells from T-lymphocyte-mediated immunosurveillance. Recent studies of previously identified viral immunomodulatory proteins reveal the allelic specificity of these proteins, their ability to function in xenogeneic systems and the difficulty in translating in vitro data to in vivo models; moreover, new mechanisms of viral modulation of MHC expression have emerged.

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页码：94 / 99

页数：6

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