Making innate sense of mRNA vaccine adjuvanticity

被引：72

作者：

Kobiyama, Kouji ^{[1
,2
,3
]}

Ishii, Ken J. ^{[1
,2
,3
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Vaccine Sci, Tokyo, Japan

[2] Univ Tokyo, Inst Med Sci, Int Vaccine Design Ctr, Tokyo, Japan

[3] Natl Inst Biomed Innovat Hlth & Nutr, Ctr Vaccine Adjuvant Res, Osaka, Japan

来源：

NATURE IMMUNOLOGY | 2022年 / 23卷 / 04期

关键词：

D O I：

10.1038/s41590-022-01168-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

mRNA vaccines such as those used to prevent COVID-19 owe part of their success to methylation that masks immunostimulatory properties of the mRNA, but the immunological mechanisms of adjuvanticity are unclear. Two new studies reveal distinct mechanisms for innate sensing of this hidden adjuvant.

引用

页码：474 / 476

页数：3

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