Dendritic cell subsets and immune regulation in the lung

被引：103
|
作者：
de Heer, HJ [1 ]
Hammad, H [1 ]
Kool, MA [1 ]
Lambrecht, BN [1 ]
机构：
[1] Erasmus Univ, Ctr Med, Dept Pulm Med, NL-3015 GE Rotterdam, Netherlands
来源：
SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 04期
关键词：
lung; dendritic cell; asthma; T helper 2 lymphocyte; sensitization;
D O I：
10.1016/j.smim.2005.05.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The lung is continuously exposed to inhaled particles, microbes and harmless antigens to which either immunity or tolerance is induced. Dendritic cells are mainly recognized for their extraordinary capacity to induce a primary immune response in the lung. Recent evidence suggests that particular subsets of DCs are essential in the decision between immunity or tolerance. Moreover, DCs play an essential role during secondary immune responses in the lung, where they control the inflammatory reaction. These novel concepts are of particular interest in understanding the pathogenesis of asthma, a disorder of aberrant immune reactivity to inhaled harmless allergens. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：295 / 303
页数：9
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