Effect of chronic morphine administration on glucose tolerance and insulin binding to isolated rat adipocytes

被引：6
作者：
Sood, A
Thakur, VS
Karmarkar, MG
Ahuja, MMS
机构：
[1] So Illinois Univ, Sch Med, Dept Internal Med, Div Endocrinol Metab & Mol Med, Springfield, IL 62794 USA
[2] All India Inst Med Sci, Dept Endocrinol & Metab, New Delhi 110029, India
[3] All India Inst Med Sci, De Addict Ctr, New Delhi 110029, India
来源：
ENDOCRINE RESEARCH | 2001年 / 27卷 / 1-2期
关键词：
D O I：
10.1081/ERC-100107182
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Morphine addiction was induced in six male Wistar rats. Improved glucose tolerance (peak value less by 28%, p < 0.01) was observed in chronically morphinized rats as compared to the control rats, injected with saline. An increase in the maximal specific binding of I-125-labeled insulin to unit membrane area of adipocytes was observed in the experimental group (p < 0.01). The changes in insulin receptor number could be responsible for the improved glucose tolerance observed during morphine addiction.
引用
收藏
页码：215 / 221
页数：7
相关论文
共 21 条
  • [1] IMPAIRED GLUCOSE-METABOLISM IN HEROIN AND METHADONE USERS
    CERIELLO, A
    GIUGLIANO, D
    PASSARIELLO, N
    QUATRARO, A
    DELLORUSSO, P
    TORELLA, R
    DONOFRIO, F
    [J]. HORMONE AND METABOLIC RESEARCH, 1987, 19 (09) : 430 - 433
  • [2] CHOPRA R. N., 1930, INDIAN JOUR MED RES, V18, P15
  • [3] INSULIN-RECEPTOR INTERACTIONS IN ADIPOSE TISSUE CELLS - DIRECT MEASUREMENT AND PROPERTIES (ASSOCIATION CONSTANT/CELL MEMBRANE/GLUCAGON/HTC CELLS/ERYTHROCYTES)
    CUATRECASAS, P
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (06) : 1264 - +
  • [4] el Daly E S, 1996, J Pharm Belg, V51, P195
  • [5] BETA-ENDORPHIN AND THE ENDOCRINE PANCREAS - STUDIES IN HEALTHY AND DIABETIC HUMAN-BEINGS
    FELDMAN, M
    KISER, RS
    UNGER, RH
    LI, CH
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1983, 308 (07) : 349 - 353
  • [6] ENDOGENOUS OPIATES DO NOT INFLUENCE GLUCOSE AND LIPID-METABOLISM IN RAT ADIPOCYTES
    HAUNER, H
    GLATTING, G
    DITSCHUNEIT, HH
    PFEIFFER, EF
    [J]. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY, 1988, 91 (03): : 350 - 354
  • [7] MORPHINE-INDUCED HYPERGLYCEMIA - ROLE OF INSULIN AND GLUCAGON
    IPP, E
    SCHUSDZIARRA, V
    HARRIS, V
    UNGER, RH
    [J]. ENDOCRINOLOGY, 1980, 107 (02) : 461 - 463
  • [8] IPP E, 1980, CLIN RES, V28, P396
  • [9] MORPHINE AND MORPHINE/NALOXONE MODIFICATION OF GLUCOSE, GLUCAGON AND INSULIN LEVELS IN FASTED AND FED RATS
    JOHANSEN, O
    TONNESEN, T
    JENSEN, T
    BURHOL, PG
    JORDE, R
    REIKERAS, O
    [J]. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1993, 53 (08) : 805 - 809
  • [10] Contribution of excitatory amino acids to morphine-induced metabolic alterations
    Meijerink, WJHJ
    Molina, PE
    Lang, CH
    Abumrad, NN
    [J]. BRAIN RESEARCH, 1996, 706 (01) : 123 - 128
123