Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

被引：56

作者：

Howe, Edward J. ^{[1
]}

Okesola, Babatunde O. ^{[1
]}

Smith, David K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 35期

关键词：

NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PHASE-CHANGE; DELIVERY; ACID; KINETICS; DERIVATIVES; ENTRAPMENT; ADSORPTION; PRODRUGS; POLYMER;

D O I：

10.1039/c5cc01868d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple supramolecular hydrogel based on 1,3:2,4-di(4-acylhydrazide)benzylidene sorbitol (DBS-CONHNH2), is able to-extract acid-functionalised anti-inflammatory drugs via directed interactions with the self-assembled gel nanofibres. Two-component hydrogel-drug hybrid materials can be easily formed by mixing and exhibit pH-controlled drug release.

引用

页码：7451 / 7454

页数：4

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